大鼠脑出血后体感诱发电位的改变与脑水肿的形成  

The change of somatosensory evoked potentials and the development of cerebral edema after intracerebral hemorrhage in rats

作　　者：秦志华[1] 朱学良[2] 刘锐[3] 

机构地区：[1]天津医学高等专科学校药理学教研室,天津300222 [2]天津医科大学病理生理学教研室 [3]天津天士力集团医学部

出　　处：《天津医科大学学报》2006年第3期432-435,442,共5页Journal of Tianjin Medical University

摘　　要：目的:使用体感诱发电位(SEP)对脑出血(ICH)模型进行评价,并观察ICH后不同时期脑水肿的形成过程。方法:采用脑立体定向术制备大鼠脑内囊出血的模型。观察大鼠在手术前及手术后不同时期内神经系统功能、SEP、脑组织形态学及脑组织含水量的改变。结果:与假手术组相比,实验组(6h、12h、1d、5d)、各波潜伏期延长(P<0.05),脑组织含水量增多(P<0.05);实验组(2d、3d)各波潜伏期明显延长(P<0.01),脑组织含水量明显增多(P<0.01);实验组(7d)各波潜伏期缩短(P>0.05),脑组织含水量减少(P>0.05)。脑组织形态学与神经系统功能呈现相应的改变。结论:SEP是评价脑立体定向术制备大鼠脑内囊出血模型的最客观指标,脑出血后脑水肿的形成是一个动态过程。Objective： To evaluate the model of intracerebral capsule hemorrhage with somatosensory evoked potentials （SEP）, and observe the development of cerebral edema during different periods after intracerebral hemorrhage （ICH） in rats. Methods： The model of ICH was established with the stereotactic method. Regional cerebral morphology, SEP, nervous symptoms, brain water content were measured during different period before and after operation. Results： Compared with the sham group, latency of SEP were prolonged （P〈0.05） in experiment group（6 h, 12 h, 1 d, 5 d）and the brain water content increased（P〈0.05）; the latency of SEP （2 d, 3 d） were prolonged significantly （P〈0.01） and brain water content increased significantly （P〈0.01）; but the latency of SEP （7 d） were shortened （P〉0.05） and brain water content decreased （P 〉0.05）. Regional cerebral morphology and nervous symptoms altered correspondingly. Conclusion： SEP is the most objective index to evaluate the model of intracerebral capsule hemorrhage in rats with the stereotactic method. The development of cerebral edema after ICH is a consecutive course. There is a directive relationship between the change of SEP and development of cerebral edema.

关 键 词：体感诱发电位 脑出血 脑水肿 

分 类 号：R743.34[医药卫生—神经病学与精神病学]