化疗前后肺癌患者CD4^+细胞因子水平的观察  

CD4^+ T cell cytokine level changes before and after chemotherapy

作　　者：朱海波[1] 翟晋芳[1] 

机构地区：[1]山西省肿瘤医院,030013

出　　处：《山西医药杂志》2006年第10期885-887,共3页Shanxi Medical Journal

摘　　要：目的观察化疗前后Th1、Th2细胞分泌的细胞因子表达的变化,探讨其与疗效的关系。方法采取小细胞肺癌(SCLC)、非小细胞肺癌(NSCLC)两组患者化疗前及化疗后2周静脉血标本,用Th1、Th2细胞因子标记流式细胞技术检测干扰素(IFN)γ-、肿瘤坏死因子(TNF)α-、白细胞介素(IL)-2、IL-4、IL-6、IL-10,分别比较SCLC及NSCLC患者化疗前后外周血CD4+细胞分泌细胞因子水平的变化。结果小细胞及非小细胞肺癌患者外周血CD4+T细胞分泌IFNγ-、TNFα-、IL-2、IL-4、IL-6、IL-10、Th1/Th2(γ/4)水平化疗前后差异无统计学意义(P>0.05)。结论针对局部晚期和晚期肺癌患者的化疗,不能纠正Th1/Th2漂移,对中晚期肺癌尤其是化疗患者,改善机体免疫功能,重建机体防御系统是很重要的治疗措施。Objective To explore the change of Thl and Th2 cytokines before and after chemotherapy and the relationship between these cytokines and therapeutic effect. Methods Venous blood sarnples of SCLC and NSCLC patients were taken before and after chemotherapy and IFN-γ,TNF-α, IL-2, IL-4, IL-6 and IL-10 were measured by flow cytometry of Th1/Th2 cytokine marked. Results IFN-γ, IL-2, TNF-α, IL-4, IL-6 and IL-10 were similar before and after chemotherapy （P 〉 0.05）. Conclusion The chemotherapy to patients with middle and advanced lung cancer can not retrieve the deflection of Th1 and Th2, while the immunotberapy for these patients is necessary.

关 键 词：药物疗法 肺癌 非小细胞 细胞因子类 

分 类 号：R734.2[医药卫生—肿瘤]