非小细胞肺癌预后相关免疫组化指标的表达及意义  

The expression and significance of immunohistochemical indexesin the prognosis of non-small cell lung cancer patients

作　　者：陈国勤[1] 顾莹莹[1] 刘芳[1] 胡帅尔[1] 莫明聪[1] 刘慕嫦[1] 杨通[1] 

机构地区：[1]广州医学院第一附属医院病理科,广东广州510120

出　　处：《中国热带医学》2006年第10期1755-1756,1852,共3页China Tropical Medicine

基　　金：广东省医学科学技术研究基金资助项目(WSTJJ20021101440102195511103224)

摘　　要：目的研究MMP-2、MMP-9、TIMP-1、TIMP-3、CD44v6、Ki-67、LDR在非小细胞肺癌的表达,筛选评价肺癌预后的有效指标。方法采用免疫组化方法标记肺非小细胞癌的组织,并对肺非小细胞癌不同类型或分期进行分析。结果肺癌组织中MMP-2、MMP-9、TIMP-1、TIMP-3、CD44v6、Ki-67蛋白表达升高,与淋巴结转移有相关性,其中以Ki-67为著;TIMP1在肺癌的病理类型、肿瘤的大小、TNM分期、淋巴结转移中都有相关性;MMP-2、MMP-9、TIMP-1、TIMP-3、Ki-67均于肿瘤的TNM分期有关。结论肺癌组织中MMP2、MMP-2、MMP-9、TIMP-1、TIMP-3、CD44v6、Ki-67均升高,可以作为预后指标的参考。Objective To observe the expression of MMP - 2.MMP - 9.TIMP- 1 .TIMP - 3.CD44v6,Ki - 67,and LDR in non - small cell lung cancer （NSCLC） patients and screen the optimum criteia for prognosis of lung cancer. Methods Immunohistochemistry（SP） was used to detect the expression of MMP - 2.MMP- 9.TIMP - 1 .TIMP - 3 .CD44v6 .and Ki - 67 in NSCLC. Re- suits The expression of MMP - 2.MMP - 9.TIMP - 1 .TIMP - 3.CD44v6 ,Ki - 67,and LDR in NSCLC was increased and correlat- ed with lymph node metastases, especially the expression of Ki - 67 was significantly increased; the expression of TIMP1 in NSCLC correlated with pathologic classification, size of tumour, TNM classification and lymph node metastases. Conclusion MMP - 2, MMP-9,TIMP- 1 ,TIMP-3,CD44v6,and Ki- 67 were highly expressed in NSCLC that can be used as indicator for prognosis of NSCLC.

关 键 词：非小细胞肺癌 肿瘤转移 预后 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]