Survivin蛋白在非小细胞肺癌组织表达及与COX-2蛋白的关系  

The expression of surviving protein in tissue of non-small cell lung cancer patients and analysis of its relationship with COX-2 protein

作　　者：张惠忠[1] 魏益平[1] 华平[1] 李海刚[1] 刘金耿[1] 吴澄[1] 

机构地区：[1]中山大学附属第二医院,广东广州510120

出　　处：《中国热带医学》2006年第10期1775-1777,共3页China Tropical Medicine

基　　金：广州市科委科技攻关引导资助项目资助(02Z3-E0016)

摘　　要：目的研究Survivin和COX-2蛋白在非小细胞肺癌(NSCLC)组织表达及与NSCLC生物学行为的关系。方法应用免疫组化方法检测77例NSCLC组织中Survivin和COX-2蛋白的表达情况,分析其与肿瘤大小、肿瘤淋巴管密度(LVD)、组织类型、分化程度、淋巴结转移、临床复发情况和术后生存时间的关系。结果77例NSCLC组织中,Survivin蛋白表达呈阳性41例,阳性率为53.2%。Survivin蛋白的表达与NSCLC的LVD、淋巴结转移、临床复发呈正相关(P<0.05),与患者术后生存期呈负相关(P<0.05)。COX-2蛋白表达阳性29例,阳性率为37.7%;COX-2蛋白的表达与LVD呈正相关(P<0.05),与患者术后生存时间呈负相关(P<0.05)。Survivin和COX-2蛋白在肿瘤中的表达之间呈正相关(r=0.438,P<0.001)。结论Survivin和COX-2蛋白的表达与NSCLC患者的预后密切相关;二者在NSCLC中的抑制癌细胞凋亡方面可能存在共同的激活机制。Objective To investigate the expression of survivin and COX - 2 protein and analysis of its relationship with biological behaviors of non small cell lung carcinoma （NSCLC）. Methods Immunohistochemical staining was used to detect the expression of survivin and COX - 2 protein in 77 NSCLC cases. The correlation of expression of survivin, COX - 2 protein and tumor size, lymphatic vessel density （LVD）, histological type, differentiation, lymphoid nodular metastasis, clinical recurrence with the survival time of the patients was analyzed. Results Out of 77 cases of NSCLC, survivin and COX - 2 protein were expressed in 41 cases and 29 cases with the positive rates of 53.2% and 37.7% ,respectively. The expression of survivin protein was associated positively with LVD, lymphoid nodular metastasis and clinical recurrence （ P 〈 0.05 ）. The expression of survivin protein was associated nega- tively with the survival time of NSCLC （ P 〈 0.05） . The expression of COX - 2 protein was positively correlated with LVD （ P 〈 0. 05）but negatively correlated with survival time of cases （ P 〈 0.05） . The expression of survivin protein was associated with the expression of COX - 2 protein positively in tumor cases（r = 0.438, P 〈 0.001 ）. Conclusion The expression of survivin and COX - 2 protein are closely associated with survival time of NSCLC and there may be an activating mechanism in inhibition of apoptosis of cancer cells in NSCLC patients by the expression of survivin and COX - 2 protein.

关 键 词：肺肿墙 免疫组织化学 SURVIVIN COX-2 淋巴管形成 预后 

分 类 号：R734.2[医药卫生—肿瘤]