Effects of spinal cord stimulation on cerebrovascular flow: role of sym-pathetic and parasympathetic innervations  

颈髓电刺激增加脑血流的作用机制研究(英文)

作　　者：仲骏[1] Oren Sagher 

机构地区：[1]上海交通大学医学院附属新华医院神经外科,上海200092 [2]密歇根大学神经外科

出　　处：《Neuroscience Bulletin》2006年第5期261-266,共6页神经科学通报（英文版）

摘　　要：Objective Cervical spinal cord stimulation （SCS） has been found to augment cerebral blood flow （CBF） in a number of animal models. However, the effective use of SCS is hampered by a lack of understanding of its mechanism（s） of action. In this paper, we focus on the sympathetic and parasympathetic effects of SCS on CBF. Method SpragueDawley rats were selected for the experimental series. The animals were divided into 5 groups to underwent SCS and laser Doppler flowmeter （LDF） recordings. Control group, the animal underwent SCS and LDF recordings without any surgery of the nerve fibers and ganglia. V 1 group, the animal underwent bilateral resection of the nasociliary and post-ganglionic parasympathetic nerve fibbers. SCG group, the animal underwent bilateral resection of supper cervical ganglion. V 1 ＋ SCG group, the animal underwent both surgeries as V1- and SCG-group animals did. Sham group, the animal underwent the carotid manipulation with blunt-tipped forceps as well as the dissection of nasociliary and post-ganglionic parasympathetic nerve fibers around the ethmoidal foramen, but without cutting any nerves. Results During the SCS, the LDF was no statistical difference between the V 1 or SCG group and the control group. Yet, the effects of SCS on CBF are completely abolished in V1＋ SCG group. Conclusions Surgical interruption of both the parasympathetic and sympathetic pathways has the contradict effect on SCS-induced CBF augmentation.目的尽管颈髓电刺激(SCS)在许多动物实验中已被证实能增加脑血流,但其作用机理还不甚明了。本文将从脑血管的交感和副交感通路方面探讨SCS对脑血流的影响机理。方法对SD大鼠给予SCS并用激光多普勒(LDF)实时记录脑血流。动物分成5 组,对照组:不对神经纤维和神经节作任何手术处理;V1 组:切断双侧鼻睫状神经及其副交感节后纤维;SCS组:切断双侧颈上神经节;V1+SCG:切断双侧鼻睫状神经及其副交感节后纤维及双侧颈上神经节;假手术组:手术暴露双侧鼻睫状神经和其副交感节后纤维及双侧颈上神经节,但不切断神经纤维或神经节。结果SCS时的LDF变化在对照组、V1和SCG 组间没有显著性差异。但在V1+SCG组中,SCS的升脑血流效应却被明显抑制了。结论SCS的升脑血流效应可能是通过交感和副交感双重通路实现的。

关 键 词：spinal cord stimulation cerebral blood flow SYMPATHETIC parasympathtic laser Doppler flowmeter 

分 类 号：Q425[生物学—神经生物学]