阿昔洛韦在大鼠胃肠道吸收的研究  

The gastrointestinal tract absorption of acyclovir (ACV) in rats

作　　者：刘宏飞[1,2] 苏显英 彭博[1] 潘卫三[1] 张志宏[1] 赵欣[3] 

机构地区：[1]沈阳药科大学药学院 [2]东北制药集团沈阳市第一制药厂 沈阳 110023 [3]东北制药集团沈阳市第一制药厂

出　　处：《中国新药杂志》2006年第18期1561-1564,共4页Chinese Journal of New Drugs

摘　　要：目的:了解阿昔洛韦在大鼠胃肠道的吸收情况。方法:采用大鼠在体灌流技术,对阿昔洛韦在大鼠胃部及不同肠段的吸收进行了研究。结果:3 h后胃中吸收平均值为9．46％,在小肠上部、中部、下部和结肠段的吸收百分率分别为20．22％,15．70％,9．15％和4．59％。结论:阿昔洛韦主要在胃肠道上部吸收,但吸收亦较差。Objective： To investigate the acyclovir （ACV） absorption through gastrointestinal tract in rats. Methods： The absorption ratio of ACV at various GI segments was studied using in situ perfusion method in rats. Results： After the rats were fed for 3 hours, the absorption ratio of ACV was 9.46% at stomach; 20. 2% , 15.70% , 9.15% , 4.59% at the upper, middle, lower intestinal tracts and colon, respectively. Conclusion： Acyclovir was mostly and poorly absorbed at upper and middle intestinal tract.

关 键 词：阿昔洛韦 胃肠道 吸收 

分 类 号：R978.7[医药卫生—药品] R943.41[医药卫生—药学]