外阴癌淋巴结转移相关因素分析  

RELATIVITY ANALYSIS ON LYMPHATIC METASTASIS FACTORS OF THE VULVAR CARCINOMA

作　　者：吴强[1,2,2,3] 苏应宽[1,2,2,3] 孙志华 刘新民[1,2,2,3] 王家跃[1,2,2,3] 

机构地区：[1]山东省立医院妇产科 [2]徐州医学院附属医院妇产科 [3]山东省立医院病理科

出　　处：《徐州医学院学报》1996年第3期221-224,共4页Acta Academiae Medicinae Xuzhou

基　　金：博士生课题资金

摘　　要：对４８例外阴鳞状细胞癌的淋巴结转移相关因素进行了临床病理分析，并应用流式细胞术（ｆｌｏｗｃｙｔｏｍｅｔｒｙＦＣＭ）对其中的３１例检测了细胞增殖活力、ＤＮＡ含量、ｒａｓＰ２１等。结果显示：发生淋巴结转移的外阴癌细胞的Ｓ％、ＰＩ和ＤＩ值显著高于未发生转移者；临床期别晚、组织分化差的外阴癌的淋巴结转移率显著增高。认为临床分期、Ｓ％、ＰＩ、ＤＩ值及组织学分级是影响外阴癌淋巴结转移的重要因素。Objective : To study the clinicopathologic factors for lymphatic metastasis of the vulvar carcinoma. Methods : 48 cases of the vulvar carcinoma were analysed in clinicopathology. S%, PI (Prolificative Index), DI (DNA Index) and rasP 21 in 31 cases were studied using flow cytometry. Results : S%, PI and DI of the vulvar carcinoma with lymphatic metastases were 14.33%, 24.86 and 1.22 respectively, which were significantly higher than those with no lymphatic metastases. The lymphatic metastasis rates of vulvar carcinoma were 6.25% and 62.50% in clinical stage Ⅰ+Ⅱ and stage Ⅲ+Ⅳ, and were 9.09%, 34.78% and 2/3 in histologic degrees Ⅰ,Ⅱ and Ⅲ respectively. The lymphatic metastasis of vulvar carcinoma was related to clinical stage, S%, PI, DI and histologic degree. The survival rate after operation of the vulvar carcinoma with no lymphatic metastases was significantly higher than that with lymphatic metastases. Conclusions : Clinical stage, S%, PI, DI and histologic degree are important factors for the lymphatic metastasis of vulvar carcinoma.

关 键 词：外阴肿瘤 淋巴结转移 流式细胞术 相关分析 

分 类 号：R737.35[医药卫生—肿瘤]