两种颈淋结巴清扫术对口腔鳞癌cN_0期患者手术疗效比较:基于国内样本的Meta分析  

Comparison of surgical effects on two kinds of neck dissection in patients with oral cavity squamous cell carcinoma in cN_0 stage:a Meta analysis based on the sample in China

作　　者：杨春惠[1] 刘云生[2] 吴正华[2] 刘少华[2] 彭化海[2] 王勇[2] 

机构地区：[1]山东中医药大学附属第二医院口腔颌面外科,山东济南250001 [2]山东大学齐鲁医院口腔颌面外科,山东济南250012

出　　处：《山东大学耳鼻喉眼学报》2006年第3期259-262,265,共5页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的:采用Meta分析方法,综合定量分析国内公开发表的有关国人cN0期口腔鳞癌患者行两种颈淋巴结清扫术的疗效,为cN0期患者颈淋巴结手术处理方式提供参考依据。方法:搜集国内所有公开发表的、随访资料完整、随机性良好的、分别采用肩胛舌骨上颈淋巴结清扫术(supraomohyoid neck dissection,SOND)与根治性颈淋结巴清扫术(radical neck dissection,RND)对cN0期患者手术疗效行对比观察的相关研究。对符合条件的资料行Meta分析,计算两组间淋巴结转移复发的比数比(odds ratio,OR)。结果:在88篇报道中,有6篇符合纳入标准。标本量1 065例,其中SOND组291例,阳性97例;RND组774例,阳性236例。OR=0.87<0.05(SOND/RND),95%CI为(0.60,1.26)。两者差异无统计学意义。结论:SOND与RND对cN0期口腔鳞癌患者的手术疗效无明显差异,SOND可取代RND以提高患者生存质量。Objective： To compare the surgical effect of two kinds of neck dissection in the Chinese patients with oral cavity squamous cell carcinoma in cN0 stage using the Meta analysis in order to provide some reference for cN0 patients. Methods： All randomized controlled researches from China about the surgical effect of the supraomohyoid neck dissection（SOND） and radical neck dissection（RND） were looked through. Odds ratio was calculated between the two groups. Results： Six researches was adopted among the 88 reports. The total number of sample was 1 065. The number of test group was 291, in which 97 were positive; of control group was 774, in which 236 were positive. OR was 0.87 〈 0.05（SOND/RND） and 95% CI was （0.60, 1.26）. There was no significantly statistical difference between the two groups. Conclusions： SOND and RND have similar effect in treatment of oral cavity squamous cell carcinoma cN0 stage,therefore it is better to use SOND to improve the life quality of the patients.

关 键 词：颈淋巴结清扫术 口腔 鳞癌 鳞状细胞癌 肿瘤分期 META分析 

分 类 号：R739.8[医药卫生—肿瘤] R195.1[医药卫生—临床医学]