没食子酸稳定性研究  

Study on stability of gallic acid

作　　者：吴雪钗[1] 于波涛[1] 侯艾林[2] 胡婷婷[1] 陆国庆[1] 

机构地区：[1]成都军区总医院,四川成都610083 [2]泸州医学院药学系,实习生四川泸州646000

出　　处：《西南国防医药》2006年第5期484-485,共2页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的:研究没食子酸在不同条件下的稳定性。方法:采用经典恒温法考察没食子酸在不同pH值水溶液的稳定性,以及抗氧剂、强酸、强碱、强光照、强氧化、高温条件对其稳定性的影响,用反相高效液相色谱法测定其含量。结果:没食子酸在碱性、中性、强氧化条件下不稳定,在酸性环境、强光、高温条件下稳定,而不同的抗氧剂对其均有保护作用。结论:没食子酸在不同条件下稳定性不同,在实际应用中应加以考虑。Objective：To investigate the stability of gallic acid under different conditions. Methods： The stability of gallic acid in water with different pH values, anti - oxidant, strong light, strong oxidation and high temperature were examined, respectively by the classical homcothermia method. The contents of gallic acid were determined by RP - HPLC. Results： It was found that gallic acid was unstable under the conditions of basic, neutral and strong oxidizing, it was stable under the conditions of acid. strong light and high temperature and its stable could be protected by antioxidants. Conclusion： The stability of gallic acid is different under different conditions, which should be considered in preparation.

关 键 词：没食子酸 稳定性 反相高效液相色谱法 经典恒温法 

分 类 号：R284[医药卫生—中药学]