内酯型去甲二萜生物碱的合成  

Synthesis of novel lactone-type norditerpenoid alkaloids

作　　者：季红[1] 王锋鹏[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2006年第5期413-415,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:30472075)

摘　　要：目的合成内酯型去甲二萜生物碱。方法塔拉萨敏经Jone’s氧化和Baeyer-V illiger氧化反应,合成了两种内酯型去甲二萜生物碱。单乙酰塔拉萨敏裂解C7-C17键后,经水解、Jone’s氧化、Baeyer-V illiger氧化及还原等共5步反应,合成了7,17-次裂的内酯型去甲二萜生物碱。结果和讨论所得产物的结构经MS1、HNMR和13CNMR确证。OBJECTIVE To synthesize lactone - type norditerpenoid alkaloids. METHODS Two kinds of lactone - type norditer- penoid alkaloids were synthesized from talatisamine as the starting material through Jone＇ s oxidation and Baeyer - Villiger oxidation. 7, 17 - seco - lactone - type norditerpenoid alkaloids was prepared with the starting material 14 - acetyhalatisamine through five steps. RESULTS and CONCLUSION The structures of the products were confirmed by MS, ^1HNMR and ^13CNMR.

关 键 词：Baeyer—Villiger氧化 内酯型去甲二萜生物碱 合成 

分 类 号：R914[医药卫生—药物化学]