辣椒素对大鼠肠系膜下神经诱发动作电位的影响  

Effects of Capsaicin on Induced Action Potential of Inferior Mesenteric Nerves in Rats

作　　者：宋晶[1] 刘艳芳[1] 张冲[1] 管慧[1] 张艳萍[1] 朱宝长[1] 

机构地区：[1]首都师范大学生命科学学院,北京100037

出　　处：《生物技术通讯》2006年第4期590-592,共3页Letters in Biotechnology

基　　金：国家自然科学基金项目(30270197)

摘　　要：目的:探讨辣椒素对肠系膜下神经诱发动作电位的影响。方法:对大鼠肠系膜下神经节施加不同浓度(分别为2.5、5、10g/L)的辣椒素或其载体(对照)后,在其中枢端给予能引起反应的方波刺激,记录节后神经外周端的动作电位。结果:虽然实验动物存在个体差异,且辣椒素对其神经作用的阈值也有所不同,但在大多数情况下,当辣椒素浓度为2.5～5g/L、作用3min后,即可使神经的敏感性降低;并表现出了较为明显的剂量相关性,即随着辣椒素浓度的升高,其对神经的脱敏作用也逐渐增强。结论:辣椒素对肠系膜下神经节内的交感和副交感神经均具有抑制作用。Objective： Previous studies have shown that capsaicin has multiple effects on nervous system; the present investigation is focus on exploring its effects on inferior mesenteric ganglion（IMG） in rat. Methods： Capsaicin was administrated to IMG for 3 min with concentration of 2.5, 5, 10 g/L or its solvent, respectively, then, central part of the nerve was stimulated by rectangular pulse higher than its threshold（0.2 ms） and the potential in the peripheral part was recorded. Results： Although there were individual differences, capsaicin at the concentration of 2.5-5 g/L usually decreased the sensitivity of nerves in dose-depended manner. Conclusion： Capsaicin has inhibiting effects on the conduction of sympa- thetic and parasympathetic nerve in IMG nerves.

关 键 词：辣椒素 肠系膜下神经节 动作电位 

分 类 号：Q42[生物学—神经生物学]