致肾盂肾炎大肠杆菌的毒力因子和调控  

Virulence Factors of Uropathogenic Escherichia coli

作　　者：王秡 张兆山[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》2006年第4期609-613,共5页Letters in Biotechnology

摘　　要：致肾盂肾炎大肠杆菌引起人的尿路感染,它的毒力因子包括表面毒力因子和分泌毒力因子两大类。表面毒力因子包括菌毛、鞭毛、黏附素和多糖类物质,主要在细菌的侵染过程中起作用。分泌毒力因子主要是溶血素、细胞毒性坏死因子等毒素蛋白,主要对宿主细胞产生毒力作用。本文简要综述致肾盂肾炎大肠杆菌毒力因子分泌所需要的5种分泌机制,并论及毒力因子的宏观调控和影响毒力调控的因素。The majority of urinary tract infections（UTI） are due to ascending infections of uropathogenic Escherichia coli （UPEC）. Virulence factors of E.coli are of two main types; those produced on the surface of the cell and those produced within the cell and then exported to the site of action. Those on the surface include different sorts of fimbriae, flagella, adhesins and LPS that have a role in invasion of host cells. The secreted virulence factors such as α-haemolysin and cytotoxic necrotising factor 1 are cytotoxinic to host cells. The five major export pathways of UPEC virulence factors across outer membrane were also summarized in this review. In the end, the paper illuminated that expression of virulence factors would be mediated by global regulators simultaneously affecting the appearance of a set of bacterial properties involved in the pathogenetic process.

关 键 词：致肾盂肾炎大肠杆菌 毒力因子 调控机制 

分 类 号：Q936[生物学—微生物学]