头孢哌酮钠中有机溶剂残留量的测定  

Studies on Determination of Solvent Residual Amount in Cefoperazone Sodium by Capillary GC

作　　者：张建立[1] 闫学斌[2] 屈红丽[2] 姬小明[2] 

机构地区：[1]许昌学院化学系,河南许昌461000 [2]郑州大学化学系新药研究开发中心,河南郑州450052

出　　处：《许昌学院学报》2006年第5期109-111,共3页Journal of Xuchang University

摘　　要：建立了采用直接进样毛细管气相色谱法测定头孢哌酮钠中丙酮和正丁醇残留量的方法．色谱柱为DB-1石英毛细管柱，柱温为150℃，载气为氮气，检测器为FID，以DMF为溶剂．在上述色谱条件下，丙酮和正丁醇的线性范围为10～90mg／L，平均加样回收率分别为100.53％和99．28％．本方法简便、专属性强、准确度高，可用于测定原料药中丙酮和正丁醇的残留量．A capillary gas chromatographic method with directly sampling is established to determine the residual amount of acetone and n-butanol in cefoperazone sodium. The analytical column is DB - 1 capillary quartz column. The column temperature is 150 ℃. The cartier gas is nitrogen. The detector is FID. DMF is selected as solvent. The linear range is 10- 90 mg/L for both of acetone and n-butanol. The average recovery of acetone and n-butanol are 100.53% and 99.28%. In conclusion, the method is simple, rapid, special, precise and it could be used for the determination of the residual amount of acetone and n-butanol in drug substances.

关 键 词：毛细管气相色谱法 头孢哌酮钠 残留溶剂 丙酮 正丁醇 

分 类 号：O657.71[理学—分析化学]