血管膜切除联合羊膜移植治疗复发性免疫性角结膜炎  

Conjunctival resection combined with amniotic membrane transplantation for recurrent immunologic disorders of cornea and conjunctiva

作　　者：李绍伟[1] 王瑶[1] 

机构地区：[1]山东省眼科研究所,266071

出　　处：《眼科》2006年第3期177-179,共3页Ophthalmology in China

摘　　要：目的报告局部血管膜切除联合羊膜移植治疗复发性免疫性角结膜炎的初步临床结果。设计回顾性病例系列。研究对象病变反复发作并开始累及角膜、药物控制欠佳的泡性角膜炎患者2例、结节状巩膜炎累及角膜1例、角膜基质炎2例。方法切除局部角巩膜缘部结膜及巩膜表面变性组织,并移植相应大小的羊膜组织。术后局部免疫抑制剂治疗2￣3周,随访6￣12个月。主要指标并发症与复发情况。结果4例患者在停药4￣10个月后无复发,角膜浸润逐渐减轻,血管萎缩。1例结节状巩膜炎患者在术后12个月时病变复发,但仅局限于球结膜部位,角膜病变无复发。结论对于反复发作、病变累及角膜的免疫性角结膜炎,局部球结膜切除联合羊膜移植可以阻止角膜病变的进展。(眼科,2006,15:177-179)Objective To report the clinical results of the treatment for recurrent immunologic disorders of cornea and conjunctiva by conjunctival resection with amniotic membrane transplantation（AMT）. Design A retrospective clinical case series. Participants Five patients 5 eyes with recurrent immunologic disorders of cornea and conjunctiva were enrolled into this study, including 2 eyes of phlytenular keratoconjunctivitis with corneal lesion, 1 eye of nodular episcleritis, 2 eyes of corneoscleral interstitial keratitis. Methods Patients were treated with partial conjunctiva resection and AMT. After operation, steroids and cyclosporin eye-drops were given for 2-3 weeks, and patients were followed up for 6-12 months. Main Outcome Measures Complications and recurrent situations were observed. Results The corneal disease kept quiescent, and the blood vessel subsidized. There were no recurrences during the follow up period in 4 cases. Recurrent signs were noted in one patient at 12 months after surgery. But no recurrence of corneal lesion was noted although the conjunctivitis was severe. Conclusion Local conjunctiva resection combined with AMT is a useful method for recurrent cases of immunologic disorders of cornea and conjunctiva. （ Ophthalrnol CHN, 2006,15：177-179）

关 键 词：角膜炎 免疫性 羊膜移植 

分 类 号：R779.6[医药卫生—眼科]