用于肿瘤基因治疗载体的肿瘤特异性配体研究进展  

Tumor-targeting ligands used in gene therapy vector:research progress

作　　者：黄悦[1] 于继云[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850

出　　处：《军事医学科学院院刊》2006年第4期385-388,共4页Bulletin of the Academy of Military Medical Sciences

基　　金：国家"863"课题资助项目(2001AA217131)

摘　　要：肿瘤靶向基因治疗的主要目的是用靶向性的载体将治疗基因靶向传递到肿瘤细胞。本文综述了3类用于肿瘤靶向基因治疗载体的肿瘤特异性配体:天然分子、单克隆抗体和靶向性多肽,以及由它们修饰的载体系统用于靶向性肿瘤基因治疗的研究进展。A major goal of tumor-targeting gene therapy is to transfer genes efficiently to tumor cells by targeted vectors. This review describes three kinds of tumor-targeting ligands,including natural tumor-specific ligands, monoclonal antibodies and tumor-homing peptides, used as tumor-targeting moieties. When linked with them, virus or non-virus vectors can be used to deliver gene to tumor tissues or tumor vasculatures for tumor-targeting gene therapy.

关 键 词：肿瘤特异性配体 靶向基因传递 抗体 单克隆 

分 类 号：R730.59[医药卫生—肿瘤]