癫痫和抗癫痫药对事件相关电位N270的影响  

Effect of Epilepsy and Anti-epileptic Drug on Event-related Potential N270

作　　者：孙伟[1] 王玉平[2] 王薇薇[1] 王荫华[1] 吴逊[1] 

机构地区：[1]北京大学第一医院神经内科,北京市100034 [2]首都医科大学附属宣武医院神经内科,北京市100053

出　　处：《中国康复理论与实践》2006年第8期716-718,i0002,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金项目(No.30370477)

摘　　要：目的探讨癫痫患者事件相关电位N270的特征及其反映患者认知功能的价值。方法35例癫痫患者根据服药情况分为卡马西平组、丙戊酸钠组和未用药组,另设健康志愿者作为对照组。所有受试者均接受简易智力量表问卷测试,同时记录事件相关电位。结果3组患者的N270差异曲线峰潜伏期长于对照组,波幅低于对照组,其中丙戊酸钠组患者的峰波幅低于其他3组(P<0.05)。患者组P300峰波幅低于对照组,丙戊酸钠组的波幅低于其他3组(P<0.05)。结论癫痫患者存在认知功能损害;抗癫痫药丙戊酸钠对癫痫患者处理冲突能力的损害较卡马西平明显;N270检测癫痫患者早期认知损害的敏感度高于P300。Objective To investigate the characteristics of event-related potential （ERP） N270 and the value of ERP N270 to detect the cognitive function in patients with epilepsy. Methods Thirty-five epileptics were divided into carbamazepine （CBZ） group （n 10）, valproate （VPA） group （n=10） and no treatment group （n=15） according to drugs they took, and other 10 healthy subjects were selected as the control group. All subjects were evaluated by Mini-Mental State Examination （MMSE）, and ERP was recorded at same time. Results All patients in three groups showed a delayed and smaller N270 than the control group （ P 〈0.01）. VPA group had the lowest N270 amplitude. The amplitude of P300 elicited in the match condition decreased in the VPA group compared with other three groups （ P 〈0.05）, but latency of the VPA group was not different from other three groups. Conclusion Cognitive impairment is present in epilepsy patients, and the effect of anti-epileptic drug VPA on ability of patients to process conflict is more evidence than CBZ. The sensitivity of N270 to detect early cognitive impairment in epileptics is higher than P300.

关 键 词：癫痫 卡马西平 丙戊酸钠 N270 P300 

分 类 号：R749.1[医药卫生—神经病学与精神病学]