曲安奈德玻璃体注射治疗视网膜分支静脉阻塞继发黄斑水肿  被引量:14

Intravitreal triamcinolone acetonide for the treatment of macular edema associated with branch retinal vein occlusion

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作  者:喻晓兵[1] 师自安[1] 戴虹[1] 龙力[1] 

机构地区:[1]卫生部北京医院眼科,北京100730

出  处:《中国实用眼科杂志》2006年第10期1043-1045,共3页Chinese Journal of Practical Ophthalmology

摘  要:目的观察玻璃体腔曲安奈德注射(intravitrealtriamcinoloneacetonide,IVTA)治疗视网膜分支静脉阻塞(branchretinalveinocclusion,BRVO)继发的黄斑水肿的近期疗效和安全性。方法对23例(23眼)BRVO继发的严重黄斑水肿患者,患眼行IVTA4mg/0.1ml,观察治疗前和治疗后1天、3天、1周、1个月、3个月时患者的最佳矫正视力、眼压、眼内炎性反应、晶体、眼底改变,光学相干断层扫描(opticcoherenttomography,OCT)测定黄斑区视网膜厚度变化。结果所有23眼中,有20眼(86.9%)视力提高,3眼(13.1%)视力不变。LogMAR视力治疗前为:0.75±0.48,治疗后一周、一个月、三个月时分别为:0.57±0.43;0.38±0.32;0.29±0.29。黄斑中心凹平均厚度治疗前为611±149μm,治疗后一周、一个月、三个月时分别为:325±129μm;208±55μm;173±38μm。治疗前后比较差异有统计学意义(P<0.01)。23眼中有3眼(13.1%)治疗后暂时性眼压轻度升高,经局部药物短期治疗后恢复正常。所有患眼未出现眼内炎、白内障、视网膜脱离、玻璃体出血等并发症。结论IVTA可以在短期内安全有效地治疗BRVO继发的黄斑水肿。Objective To evaluate the efficacy and security of intravitreal triamcinolone acetonide (IVTA) in the treatment of macular edema associated with branch retinal vein occlusion. (BRVO) Methods Twenty-one eyes of 23 patients with severe macular edema due to BRVO underwent IVTA with 4mg/0.1ml. Best-corrected visual acuity, intraocular pressure (lOP), inflammatory extent, manifestation of lens and fundus were observed before treatment and one day, three days, one week, one month, three months after treatment. The retinal thickness was examined by optic coherent tomography (OCT). Results Of all 23.eyes 20 eyes (86.9%) had improved visual acuity, 3 eyes(13.1%) remained the same. The LogMAR visual acuity was 0.75 ± 0.48 before treatment, while 1 week, 1 month and 3 months after IVTA, the average visual acuity was 0.57 ± 0.43, 0.38 ±0.32 and 0.29 ±0.29 respectively. The average retinal thickness at macular area was 611 ± 149μm before treatment, whilel week, 1 month and 3 months after IVTA, the average retinal thickness was 325 ± 129μm, 208 ± 55μm and 173 ± 38μm respectively, which had statistical significance compared with that before treatment. (P〈0.01) 3 eyes (13.1%) of all 23 eyes had high intraocular pressure (lOP) temporarily, and lOP was controlled after treated with topical eye drop. No eye developed endophthalmitis, cataract, retinal detachment, or vitreous hemorrhage. Conclusions IVTA is effective for macular edema secondary to BRVO in a short time.

关 键 词:视网膜静脉闭塞/治疗 曲安奈德/治疗应用 黄斑水肿 囊样/药物疗法 

分 类 号:R774.1[医药卫生—眼科]

 

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