Synthesis and Antitumor Activity of an Analog of Phthalascidin  

作　　者：Ye WANG Yan Li ZHOU Zhan Zhu LIU Shi Zhi CHEN Xiao Guang CHEN 

机构地区：[1]Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050

出　　处：《Chinese Chemical Letters》2006年第10期1279-1282,共4页中国化学快报（英文版）

摘　　要：An analog of phthalascidin （Pt-650） was synthesized with an improved synthetic route. With precursor 2 as the starting material, compound 1 was prepared through 4 steps in a total yield of 47%. In vitro antitumor test of this Pt-650 analog showed that it possessed strong toxicity against a number of tumor cell lines including A2780, A549, Bel-7402, BGC-823, HELA, KB, KeTr3 and HCT-8.An analog of phthalascidin （Pt-650） was synthesized with an improved synthetic route. With precursor 2 as the starting material, compound 1 was prepared through 4 steps in a total yield of 47%. In vitro antitumor test of this Pt-650 analog showed that it possessed strong toxicity against a number of tumor cell lines including A2780, A549, Bel-7402, BGC-823, HELA, KB, KeTr3 and HCT-8.

关 键 词：Ecteinascidin phthalascidin TETRAHYDROISOQUINOLINE antitumor. 

分 类 号：R979.14[医药卫生—药品]