肝脏肿瘤组织中麦胚凝集素受体的定位  

Localization of WGA Receptors in Liver Tumor Tissues

作　　者：张世民[1] 吴孟超[1] 陈汉[1] 张秀忠[1] 

机构地区：[1]长海医院肝胆外科研究所

出　　处：《第二军医大学学报》1990年第2期103-106,共4页Academic Journal of Second Military Medical University

摘　　要：采用ABC法对肝细胞癌、肝内胆管细胞癌等肝脏肿瘤中麦胚凝集素受体进行组织学定位,并以正常肝组织、肝硬变组织及癌周肝组织等为对照,结果表明:肝细胞癌中麦胚凝集素受体的不规则分布与正常肝组织、肝硬变组织中带状分布形成明显对比,与胆管细胞癌中麦胚凝集素受体的分布也有差别。用神经氨酸苷酶处理后,麦胚凝集素受体的分布有明显变化。提示:细胞内麦胚凝集素受体的分布特点有利于肝脏肿瘤的诊断和鉴别诊断。Receptors of wheat germ agglutinin (WGA) in liver tumors, such as hepatocellular carcinoma (HCC), intrahepatic cholangiocellular carcinoma(ICC) and so on, were histologically localized by avidin-biotin-peroxidase complex (ABC) method. Normal, cirrhostic and pericarcinomatous liver tissues were used as controls. The result showed that WGA receptors in HCC were irregularly distributed, which was significantly different to the band-like distribution of WGA receptors in the controls and to the distribution in ICC. After the treatment with neuraminidase, the distributions of WGA receptors changed apparently. It is suggested that the characteristics of WGA receptor distributions in cells could be helpful to the diagnosis and differential diagnosis of liver tumors.

关 键 词：肝脏肿瘤 麦胚凝集素 受体 定位 

分 类 号：R735.704[医药卫生—肿瘤]