强迫症患者血浆P物质浓度的研究  

Study of P substance concentration in obsessive-compulsive disorder

作　　者：周云飞[1] 张亚林[2] 胡纪泽[1] 刘铁榜[1] 刘妹 闫小华[1] 余常红[1] 吴东辉[1] 

机构地区：[1]深圳市康宁医院,深圳518003 [2]中南大学湘雅二医院精神卫生研究所 [3]深圳市人民医院

出　　处：《中国行为医学科学》2006年第10期899-900,共2页Chinese Journal of Behavioral Medical Science

基　　金：深圳市科技计划资助项目(JH200505180193A)

摘　　要：目的比较强迫症患者与正常人群的P物质含量差异,以及强迫症患者P物质含量与其性别、病程及强迫症状严重程度的关系。方法用酶联免疫吸附反应方法测定P物质含量,采用耶鲁布朗强迫症量表评估强迫症状。结果强迫症患者的血浆P物质含量(90.41±41.83)pg/ml较正常人(111.63±49.59)pg/ml显著性低(P<0.05)。不同性别之间P物质含量差异无显著性男性(93.45±44.66)pg/ml,女性(113.80±56.35)pg/ml,P>0.05,P物质含量与病程(r=-0.014,P>0.05)及严重程度(r=0.252,P>0.05)无明显相关。结论强迫症的P物质含量可能与强迫症的发病有关,而与其性别、病程和症状严重程度无关。Objective To compare the P substance （SP） concentration of obsessive-compulsive disorder （OCD） and normal controls,and the relationship between SP concentration and sex, duration of illness, severity of symptom in OCD. Methods SP concentration was detected by ELISA,and YBOCS was used to assessed symptom of OCD patients. Results P substance concentration of OCD [ （90.41 ± 41.83） pg/ml] was significant lower than that of normal controls [ （111.63 ± 49.59）pg/mll （ P = 0. 044） ; No significant correlations were found between SP concentration and sex （ P= 0.496） , duration of illness （ r = - 0.014, P 〉 0.05 ） , severity of symptom （ r = 0. 252, P〉 0.05） in OCD. Conclusion P substance might play an role in the progression of OCD, and was no significant correlative with sex, duration of illness, severity of symptom in OCD.

关 键 词：强迫症 P物质 病程 症状 

分 类 号：R749.7[医药卫生—神经病学与精神病学]