睡眠剥夺对脑事件相关电位P_(300)的影响  

Effects of sleep-deprivation on event-related-potential P_(300)

作　　者：付兆君[1] 马瑞山[1] 崔丽[1] 徐先荣[1] 郑军[1] 刘晶[1] 

机构地区：[1]中国人民解放军空军总医院,北京100036

出　　处：《中国行为医学科学》2006年第10期922-923,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的探讨睡眠剥夺对脑事件相关电位P300潜时及波幅的影响。方法8名男性被试参加了自7:00至次日8:00的睡眠剥夺实验。在此过程中进行了9次反复的手控跟踪+听觉Oddball双任务,实验中记录跟踪误差、反应时,同时记录分析脑事件相关电位P300潜时和波幅。结果在睡眠剥夺的夜间反应时延长7:00为(463.0±12.0)ms,4:00为(510.4±12.4)ms,跟踪误差增大7:00为(35.5±2.9)mm,4:00为(49.8±6.5)mm;同时P300潜时延长7:00为(383.0±8.2)ms,4:00为(420.5±7.7)ms、波幅降低7:00为(10.5.0±0.8)mV,4:00为(6.9±1.0)mV;反应时的变化幅度与P300潜时基本一致。结论在睡眠剥夺的夜间,大脑接受和处理信息的速度的降低是反应时延长的主要原因。Objective To investigate the effects of sleep-deprivation on latency and amplitude of event-related-potential P300. Methods 8 men participated the sleep-deprivation test from 7：00 to 8：00 of the next day. During sleep-deprivation they performed a visual tracing plus aural reaction task in oddball mode repeatedly for 9 times, and the tracing-error and reaction-time were recorded automaticly by PC. At the same time the EEG were recorded and were analysised to get the event-related-potencial P30o. Results The reaction-time prolonged [ （463.0 ±12.0 ） ms at 7：00, （510.4 ± 12.4） ms at 4：00 ] and the tracing-error increased [ （35.5 ± 2.9）mm at 7：00, （49.8 ± 6.5 ） mm at 4：00 ] significantly at night of sleep deprivation （ P 〈 0.01 ）. The latency of P300 prolonged [ （ 383.0 ± 8.2 ） ms at 7：00, （420.5 ± 7.7 ） ms at 4：00 ] and the amplitude of P30o decreased [ （ 10.5.0 ± 0.8） mV at 7：00, （6.9 ± 1.0） mV at4：00 ]. The changing of reaction-time and latency of P300 was similar. Conclusion The decreased speed of brain receiving and treating information play an important role in the prolonged reaction-time at night of sleep deprivation.

关 键 词：睡眠剥夺 反应时 事件相关电位 

分 类 号：R740[医药卫生—神经病学与精神病学]