新型高效除草剂噻磺隆合成新工艺  

New Methodology for Synthesis of Novel Herbicide Thifensulfuron

作　　者：李春仁[1] 陆阳[2] 陶京朝[2] 张志荣[3] 李门双[4] 

机构地区：[1]信阳职业技术学院机电化工工程系,河南信阳464000 [2]郑州大学化学系,河南郑州450001 [3]安徽省华祥农药化工公司,安徽合肥230041 [4]信阳农业高等专科学校,河南信阳464000

出　　处：《山西化工》2006年第5期19-21,共3页Shanxi Chemical Industry

摘　　要：介绍了以氯甲酸甲酯和2-羧甲基-3-磺酰氨基噻吩为起始原料合成除草剂噻磺隆的方法。原料2-羧甲基-3-磺酰氨基噻吩与氯甲酸甲酯生成2-甲氧羧基-3-磺酰氨基甲酸甲酯噻吩,再与2-氨基-4-甲氧基-6-甲基均三嗪反应生成噻磺隆。避免了异氰酸酯路线的种种缺点,具有收率高、含量高和成本低的特点。以2-羧甲基-3-磺酰氨基噻吩计,总收率为77.73%,原药纯度达到93.6%。A method for preparation of thifensulfuron from methyl chlorformate and 2-methoxycarbonyl-3-aminosulfonylthiophe as starting material was reported. First, 2-methoxycarbonyl-3-aminosulfonylthiophene reacts with methyl chloroformate to give 2- methoxycarbonyl-3-amlnosulfonyl methyl formatethiophene, then thifensulfuron was obtained after the reaction of the above product with 2-amino-4-methoxy-6-methyl-1,3,5-triazine. This is an economical method to prepare thifensulfuron with high yield and good purity, and it avoids the shortcoming of the isocyanate route. The total yield reaches 77.73% and the purity is 93.6% based on 2- methoxycarbonyl-3- aminosul fonylthiophene.

关 键 词：噻磺隆 氯甲酸甲酯 磺酰脲 除草剂 

分 类 号：TU457.2[建筑科学—岩土工程]