血液稀释与输异体血对肝癌病人T细胞亚群的影响  

Effect of perioperative allogeneic blood transfusion and acute blood dilution in equal-capability on T lymphocyte subsets in patients with liver cancer

作　　者：谭立清[1] 黄中华[1] 张庆敏[1] 刘燕洁[1] 黄小彬[1] 秦丹丹[1] 

机构地区：[1]广西壮族自治区人民医院麻醉科,南宁530021

出　　处：《广西医学》2006年第10期1501-1502,共2页Guangxi Medical Journal

基　　金：广西科学基金项目(桂科自9824003)

摘　　要：目的探讨围术期急性等容血液稀释自身输血与输异体血对肝癌病人及T细胞亚群的影响。方法20例肝癌病人,随机分为输异体血组、急性等容血液稀释组。分别于术前及术后24h、48h、72h120h抽取静脉血测定T细胞亚群CD2、CD4、CD8、CD4/CD8。结果血液稀释组T细胞亚群在术前术后改变不明显(P>0.05)。输异体血组在术后48h后CD2、CD4、CD4/CD8降低(P<0.01),120h尚未恢复到术前水平。结论围术期急性等容血液稀释对T细胞亚群的应响不大,而输异体血对及T细胞亚群有明显的抑制作用。Objective To investigate effect of perioperative allogeneic or autologous blood transfusion on T lymphocyte subsets in patients with liver cancer. Methods 20 liver cancer patients were randomly divided into autologous blood transfusion group and allogenenic blood transfusion group with 10 patients in each group . Blood ,sample were drawn before operation and 24h ,48h,72h after operation to determine the count of CD2, CD4,CD8 ,CD4/CD8 .Results T lymphocyte subsets had no significant change in autologous blood transfusion group .The count of CD2 CD4 CD4/CD8 rose and CD8 drop pped 24h after operation in allogenenic blood transfusion group, the change could not resume to the level of pre-operation. Conclusion T lymphocyte subsets are suppressed by perioperative allogeneic transfusion but not influnced by perioperative acute blood dilution in equal-capability.

关 键 词：围术期急性等容血液稀释 输血 肝癌 T细胞亚群 

分 类 号：R735.7[医药卫生—肿瘤] R446.3[医药卫生—临床医学]