脉络膜缺血TXB_2和6－keto－PGF_（1α）变化及其治疗的实验研究  

Changes of TXB2 and 6-keto-PGF1α and effects of compound anisodine I during experimental choroidal ischemia

作　　者：申维勇[1] 宋琛[1] 杨梅芳[1] 韩素义 

机构地区：[1]解放军总医院眼科,解放军总医院生化室

出　　处：《军医进修学院学报》1996年第1期7-9,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：采用切断兔眼部分睫状后短动脉造成脉络膜缺血的动物模型，测定脉络膜血栓素Ｂ２（ＴｈｒｏｍｂｏｘａｎｅＢ２，ＴＸＢ２）和６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ｐｒｏｓｔａｇｌａｎｄｉｎＦ１α，６－Ｋｅｔｏ－ＰＧＦ１ｄ）的含量，并观察复方樟柳碱１号（Ｃｏｍｐｏｕｎｄａｎｉｓｏｄｉｎｅ１，ＣＡ－１）对其影响。结果表明，缺血１ｈＴＸＢ２及６－Ｋｅｔｏ－ＰＧＦ１ｄ升高；２４ｈ时６－Ｋｅｔｏ－ＰＧＦ１α已呈下降趋势而ＴＸＢ２仍处于较高水平，使ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比率升高。ＣＡ－１升高６－ｋｅｔｏ－ＰＧＦ１α并保持ＴＸＢ２和６－ｋｅｔｏ－ＰＧＦ１α之间的平衡。结果提示，缺血１ｈＴＸＢ２和６－ｋｅｔｏ－ＰＧＦ１α之间的平衡即发生变化；ＣＡ１－号改善缺血区脉络膜的微循环并可能调节缺血区血管紧张度。TXB2 and 6-keto-PGF1α were measured during choroidal ischemia caused by resecting partial poste-rior cilliary arteries in rabbits, The effects of compound anisodine I(CAI)were also investigated. The results showed that TXB2 and 6-keto-PGF1αwere temporally increased at one hour post-ischemia,and 6-keto-PGF1αwas decreased at 24 h post-ischemia while TXB2 was still high and leading an increased ratio of TXB2/6-keto-PGF1α CA-1 could increase the level of 6-keto-PGF1α,Our results indicate that the changes of TXB2 and 6-ke-to-PGF1α occur during choroidal ischemia,and that CA-1 improves the rnicrocirculation at ischemic areas and may regulate vascular tone.

关 键 词：脉络膜 缺血 前列腺素炎 动物模型 治疗 

分 类 号：R773.4[医药卫生—眼科]