结肠癌患者血清β_2-M的测定  

Detection of serum β_2-M in colon cancer

作　　者：曹志红[1] 周蓉蓉[2] 

机构地区：[1]中南大学湘雅医院检验科,湖南长沙410008 [2]中南大学湘雅医院肿瘤科,湖南长沙410008

出　　处：《中国医学工程》2006年第4期394-395,共2页China Medical Engineering

摘　　要：目的探讨血清β_2-微球蛋白(β_2-M)对结肠癌的诊断意义。方法放射免疫法(RIA)测定50例正常对照组和53例结肠癌患者的血清β2-M,并对结果进行统计分析。结果正常对照组血清β2-M为(1.95±0.52)mg/L,结肠癌组为(4.10±1.74)mg/L,两者比较差异有显著性,以血清β2-M≥2.99mg/L为阳性判断标准,结肠癌组平均阳性率为76%。结论血清β2-M对结肠癌的诊断有一定价值,联合其他肿瘤标志物能提高检出阳性率,但要排除非肿瘤因素的干扰。[Objectives] To investigate the diagnostic significance of serum β2-Microglobutin in colon cancer. [Methods] Serum β2-Microglobufin of 50 cases of controlled groups and 53 cases of colon cancers were detected by radioimmunoassay and the results were analysed statistically. [Results] Serum β2-M of controlled groups was 1.95±0.52 mg/L, and that of colon cancers was 4.10±l.74mg/L. The difference of serum β2-M between two groups were statistically significant. The positive standard of serum β2-M was equal with or beyond 2.99 mg/L. The mean positive rate of colon cancers was 76%. [Conclusions] The serum β2-M has some diagnostic evaluation in colon cancer, and was helpful in early diagnosis of colon cancer with other methods, but should rule out the possibility of non-cancer factor interference

关 键 词：Β2-微球蛋白 结肠癌 

分 类 号：R735.35[医药卫生—肿瘤]