精神分裂症患者伴发代谢综合征的相关因素  

Factors Related to Hospitalized Schizophrenics with Metabolic Syndrome

作　　者：张本[1] 王丰[1] 王学义[2] 陆林[3] 吴寿岭[1] 周永[4] 王静[1] 王克强[5] 马启民[5] 陶钧 刘文勇 张武文[8] 

机构地区：[1]华北煤炭医学院附属开滦医院,唐山063000 [2]河北医科大学第一附属医院,石家庄050031 [3]北京大学药物依赖性研究所,北京100083 [4]首都医科大学,北京100059 [5]河北省荣军医院,保定071000 [6]河北省张家口市沙岭子医院,张家口075131 [7]中国精神康复唐山试点医院,唐山063001 [8]河北省秦皇岛市九龙山医院,秦皇岛066000

出　　处：《中国心理卫生杂志》2006年第10期661-664,共4页Chinese Mental Health Journal

摘　　要：目的:探索住院精神分裂症患者伴发代谢综合征的相关因素。方法:抽取5个地区5家医院的住院精神分裂症患者,调查伴发代谢综合征的相关因素。内容包括:年龄、病程、精神病药物与剂量、空腹血糖、血脂等。结果:资料完整的797例住院精神分裂症患者,伴发代谢综合征者共153例(19．2％)。病程长、服用氯氮平、服用药物时间长、高剂量用药患者MS发生率高(P<0．05、P<0．01);L0gistic回归分析显示:代谢综合征的危险因素有高龄、服用氯氮平、CRP浓度偏高、吸烟、服用抗精神病药物时间长。结论:影响住院精神分裂症患者伴发代谢综合征的相关因素有氯氮平、病程、用药时间、吸烟等。Objective： To explore the relative factors of hospitalized schizophrenics with metabolic syndrome. Methods： Patient＇s data were collected by the way of face-to-face questionnaire to patients or their guardians, consulting patient＇s medical record, checking physical or laboratory examination. Information include＇ age, duration of the disease, the classification of antipsychotics and dosage, fast plasma glucose, plasma lipids, blood pressure, etc of hospitalized schizophrenics. The relative factors of metabolic syndrome were analyzed. Results： Among 797 schizophrenics, there were 153 cases （19.2%） suffered from metabolic syndrome. Single-factor analysis showed that the patients with longer duration of the disease, taking clozapine, ete, were at high risk of metabolic syndrome, and sex didnt relate to metabolic syndrome; Logistic regression analysis appeared that metabolic syndrome correlated with age, clozapine, CRP concentration, etc. Conclusion： The possible risk factors causing metabolic syndrome in schizophrenia include, duration of the disease, etc.

关 键 词：精神分裂症 相关因素 代谢综合征 横断面研究 

分 类 号：R749.3[医药卫生—神经病学与精神病学]