乳腺原发性血管肉瘤的临床及病理学特征  

Clinical and pathologic characteristics of primary angiosarcoma of breast

作　　者：刘红[1] 赵晶[1] 范宇[2] 傅西林[2] 付丽[2] 

机构地区：[1]天津医科大学附属肿瘤医院乳腺科,300060 [2]天津医科大学附属肿瘤医院乳腺病理科,300060

出　　处：《中华病理学杂志》2006年第10期598-601,共4页Chinese Journal of Pathology

摘　　要：目的探讨乳腺原发性血管肉瘤的临床及病理特点。方法复习5例乳腺原发性血管肉瘤切片,依据2003年 WHO 乳腺肿瘤组织学分类标准诊断和分级。采用第Ⅷ因子相关抗原、CD31、CD34、雌激素受体(ER)、孕激素受体(PR)、细胞角蛋白(CK)及 c-erbB-2等抗体进行免疫组织化学 SP 法染色观察。结果 5例患者均以乳腺无痛性肿块为首发症状,术前 B 超、钼靶检查缺乏特异性诊断。组织学呈多样性表现是乳腺血管肉瘤组织学形态特点。免疫组织化学染色显示,5例血管内皮相关抗原均呈阳性表达,ER、PR、CK 及 c-erbB-2均阴性。结论乳腺原发性血管肉瘤非常罕见,临床表现缺乏特异性,病理形态多样,诊断困难,血管内皮相关抗原均呈阳性表达对确诊有帮助。Objective To study the clinical and pathologic characteristics of primary angiosarcoma of breast. Methods Five cases of primary angiosarcoma of breast were reviewed. Immunohistochemical study （SP method） for factor Ⅷ-related antigen, CD31 , CD34, estrogen receptor, progesterone receptor and c-erbB-2 was performed. The clinical data were also analyzed. Results All of the 5 patients had a history of a painless breast lump. Ultrasound examination and mammogram did not reveal any specific findings. Histologically, various degree of cellular pleomorphism was noted. Immunohistochemical study showed a positive expression of endothelial associated antigens of the tumors cells in all the 5 cases. The staining result for estrogen receptor, progesterone receptor and c-erbB-2 was negative. Conclusions Primary angiosarcoma of breast is a rare entity. The diagnosis is rather difficult owing to the lack of specific clinical findings and histological heterogeneity. Application of Positive expression of endothelial associated antigens of the tumors cells is helpful in making a pathological diagnosis morphologically.

关 键 词：乳腺肿瘤 血管肉瘤 诊断 鉴别 

分 类 号：R737.9[医药卫生—肿瘤]