细胞外基质金属蛋白酶诱导因子和内皮素转化酶对非小细胞肺癌患者术后淋巴结转移和预后的影响  

Significance of expression of extracellular matrix metalloproteinase inducer and endothelin converting enzymes in lymphoid metastasis and prognosis in non-small-cell lung carcinoma

作　　者：张惠忠[1] 李海刚[2] 魏益平[1] 刘金耿[1] 吴澄[1] 曹永科[1] 王梅[1] 

机构地区：[1]中山大学附属第二医院心胸外科,广东广州510120 [2]中山大学附属第二医院病理科,广东广州510120

出　　处：《中国病理生理杂志》2006年第10期2018-2021,共4页Chinese Journal of Pathophysiology

基　　金：广州市科委科技攻关引导资助项目(02Z3-E0016)

摘　　要：目的:研究细胞外基质金属蛋白酶诱导因子(EMMPR IN)和内皮素转化酶(ECE)在非小细胞肺癌(NSCLC)组织中表达的临床意义。方法:用免疫组织化学方法检测77例NSCLC组织中EMMPR IN和ECE的表达情况,分析其与肿瘤大小、癌的组织学类型、组织分化程度、淋巴结转移和预后的关系。结果:77例NSCLC组织中EMMPR IN和ECE的阳性表达率分别为66%和45%。EMMPR IN和ECE的表达均与淋巴结转移呈正相关(均P<0.01,r=0.371和0.467),两者表达阳性组术后生存期均明显短于阴性组(均P<0.01)。NSCLC组织中EMMPR IN和ECE的表达之间呈正相关(P<0.05,r=0.243)。EMMPR IN和ECE的表达与肿瘤大小、癌组织学类型和组织分化程度均无相关性(P>0.05)。结论:EMMPR IN和ECE的表达与NSCLC的淋巴结转移和预后密切相关,它们的高表达提示非小细胞肺癌患者预后不良。AIM： To investigate the expression of extracellular matrix metalloproteinase inducer （EMMPRIN） and endothelin converting enzymes （ECE） in non - small - cell lung carcinoma （ NSCLC）, and their relationship with lymphoid metastasis and prognosis. METHODS： Expression of EMMPRIN and ECE in 77 cases of patients with NSCLC was detected immunohistochemically. The relationship of the expression of EMMPRIN and ECE with tumor size, histological type, differentiation, lymphoid metastasis, clinical stage, and prognosis were analyzed. RESULTS： The expressive rate of EMMPRIN and ECE was 66% and 45% , respectively. The expression of EMMPRIN and ECE was associated positively with lymphoid metastasis （ both P 〈 0. 01, r = 0. 371 and 0. 467, respectively）, and inversely with survival time （ P 〈 0. 01 and P 〈 0. 01 ）. No relationship was found in the expression of EMMPRIN and ECE with tumor size, histological type, and differentiation （P 〉 0. 05）. The expression of EMMPRIN was associated with the expression of HGF in NSCLC （P 〈 0.05, r = 0. 243 ）. CONCLUSION ： The expression of EMMPRIN and ECE is associated with lymphoid metastasis and prognosis in NSCLC. Overexpression of EMMPRIN and ECE implies infavourable prognosis in NSCLC.

关 键 词：肺肿瘤 免疫组织化学 细胞外基质金属蛋白酶诱导因子 内皮素转化酶 淋巴转移 预后 

分 类 号：R734.2[医药卫生—肿瘤]