CD44v6和LYVE-1蛋白在卵巢上皮性肿瘤中的表达及意义  

Clinical Significance of Expression of CD44v6 and LYVE-1 in Epithelial Ovarian Tumor

作　　者：陈睿[1] 汪蕊[1] 杨婉华[1] 马湘一[1] 卢运萍[1] 王世宣[1] 马丁[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《肿瘤防治研究》2006年第10期704-706,F0003,共4页Cancer Research on Prevention and Treatment

基　　金：国家重点基础研究发展规划项目(2002CB513100);国家自然基金项目(30170976)

摘　　要：目的探讨CD44v6和LYVE-1蛋白在卵巢上皮性肿瘤中的表达及意义。方法应用免疫组化链霉菌抗生物素蛋白-过氧化物酶连接(SP)法检测CD44v6、和LYVE-1在63例卵巢上皮性癌、5例卵巢良性上皮性肿瘤和4例正常卵巢组织中的表达情况。结果正常卵巢组织、卵巢良性上皮性肿瘤和卵巢上皮性癌中CD44v6和LYVE-1蛋白的表达具有显著差异;CD44v6表达强度与卵巢癌临床分期和组织学分级呈正相关,LYVE-1的表达和卵巢癌的临床分期正相关,而不同组织学分级间差异无显著性;CD44v6和LYVE-1的表达强度与淋巴结有无转移显著相关;CD44v6和LYVE-1在卵巢癌中协同表达。结论CD44v6和LYVE-1在卵巢癌发生发展、和淋巴转移中起不同程度的作用,其检测可为卵巢肿瘤生物学行为判定提供参考依据。Objective To determine the expression of CD44v6 and LYVE-1. in epithelial ovarian tumor and its clinical significance, Methods The expression of CD44v6 and LYVE-1 was examined by immunohisto-chemical streptravidin-biothin peroxidase（SP） assay, The correlation between their expression and the clinicopathological features was analyzed, Results The expression of CD44v6 and LYVE-1 increased significantly in ovarian epithelial cancer compared to that in benign ovarian epithelial tumors and normal ovarian tissues, The expression of CD44v6 was positively associated with the FIGO stages and WHO grades of the patients with ovarian epithelial cancer, The expression of LYVE-1 was significantly related to the stages, The expression of CD44v6 and LYVE-1 was significantly associated with lymph node status, There was statistically significant correlation between CD44v6 and LYVE-1, Conclusion CD44v6 and LYVE-1 played certain roles in oncogenesis, progression and lymphatic metastasis of ovarian cancer.

关 键 词：卵巢上皮性肿瘤 CD44V6 LYVE-1 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]