A preliminary study on the econazole induced endoplasmic reticulum related apoptosis in HL-60 leukemic cells  

作　　者：Zhenping Hu Wenli Liu Stuart Berger Yicheng Zhang 

机构地区：[1]Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China [2]Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China [3]Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M9, Canada

出　　处：《The Chinese-German Journal of Clinical Oncology》2006年第5期376-378,共3页中德临床肿瘤学杂志（英文版）

摘　　要：Objective： To investigate the anti-leukemic function of econazole （Ec）, an azole anti-fungal drug. Methods： We compared efficacy of econazole to induce apoptosis in HL-60 cells with two other known endoplasmic reticulum （ER） stress inducer thapsigargin （Tg） and tunicamycin （Tu）. Results： Cells treated with Ec showed typical morphology of apoptosis following 24 h incubation, parallel to the morphological changes, the expression of molecular chaperone GRP 78 was up-regulated in all cases and the caspase 12, an ER resident caspase was activated. Conclusion： Ec induced ER stress related apoptosis in HL-60 cells; the underlying mechanisms are protein synthesis inhibition through eIF20α phosphorylation and caspase 12 activation.

关 键 词：LEUKEMIA endoplasmic reticulum stress APOPTOSIS 

分 类 号：R733.7[医药卫生—肿瘤]