儿童抽动障碍事件相关电位N400的研究  

Study of event-related potentials N400 in children with Tic disorders

作　　者：胡莲清[1] 郑璇[2] 欧利民[2] 林丽丽[3] 郭继忠[1] 庄伟端[2] 吴育彬[2] 郑俊忠[2] 

机构地区：[1]汕头大学医学院附属第一医院儿科,515041 [2]汕头大学医学院附属第一医院神经科,515041 [3]汕头大学医学院附属第一医院脑电图室,515041

出　　处：《临床神经病学杂志》2006年第5期379-380,共2页Journal of Clinical Neurology

基　　金：广东省卫生厅基金资助课题(A2003500)

摘　　要：目的探讨儿童抽动障碍患者事件相关电位N400的变化及其意义。方法用诱发电位检测仪测定35例抽动障碍患儿(病例组)的N400,并与20名正常儿童(正常对照组)进行比较。结果病例组N400的潜伏期为(706.87±198.99)ms,波幅为(26.12±13.64)μV,对照组为(485.75±85.76)ms和(22.35±19.76)μV。两组潜伏期比较,差异有非常显著性(P<0.001);波幅比较,差异无显著性(P>0.05)。结论抽动障碍患者的事件相关电位N400潜伏期明显延长,显示其存在认知功能障碍。Objective To investigate the change of event-related potentials （ERPs） N400 and its significances in children with Tic disorders. Methods N400 of 35 children with Tic disorders （ case group ） and 20 healthy children （control group） were taken. The results of case group and control group were compared with each other. Results N400 latency of the case group was （ 706. 87 ± 198. 99 ） ms , and the amplitude was （ 26. 12 ±13.64 ）μV ; N400 latency of the control group was （485.75 ±85.76） ms ,the amplitude was （22.35 ±19. 76） μV. There was obvious difference in latency between two groups （P 〈 0. 001 ）. While, there was no significant difference in amplitude （ P 〉 0. 05 ）. Conclusion ERPs N400 latency of children with Tic disorders prolong obviously which shows cognitive dysfunction in the patients.

关 键 词：抽动性运动障碍 事件相关电位 N400 认知功能 

分 类 号：R749.94[医药卫生—神经病学与精神病学]