C-erbB-2、MVD在卵巢肿瘤组织中的表达与CPA血流的关系  

C-erbB-2, MVD expression in ovarian tumors and their relationship to the blood flow of CPA

作　　者：金蓉[1] 李彦敏[1] 崔壮[2] 焦彤[1] 高卫平[2] 

机构地区：[1]天津第一中心医院,天津300192 [2]天津医科大学,天津300074

出　　处：《中国临床医学影像杂志》2006年第10期566-568,共3页Journal of China Clinic Medical Imaging

基　　金：天津市自然科学基金资助课题(编号:033609011)

摘　　要：目的:探讨卵巢肿瘤组织中C-erbB-2、MVD表达与CPA血流的关系。方法:对50例卵巢肿瘤患者术前应用CPA检测卵巢组织内的血流信号,测其血流阻力指数(RI),术后采用免疫组化法检测该组织中C-erbB-2、MVD的表达。结果:恶性卵巢肿瘤组织中的C-erbB-2的阳性表达率(83.33%)显著高于良性组(30%,P<0.05),其表达强度与CPA血流分级呈正相关(r=0.847,P<0.05)。良、恶性卵巢肿瘤组织中C-erbB-2阳性表达组的MVD(53.37±7.91)显著高于阴性表达组(38.93±3.19,P<0.05)。卵巢恶性肿瘤组织的MVD(48.84±6.19)显著高于良性组(20.90±2.71,P<0.05),其MVD与CPA的血流分级呈正相关(r=0.823,P<0.05)。恶性卵巢肿瘤的RI值(0.36±0.06)显著低于良性组(0.68±0.07,P<0.05),其RI值与MVD呈负相关(r=-0.806,P<0.05)。结论:巢卵肿瘤组织中C-erbB-2、MVD的表达为临床应用CPA提供了可靠的病理学基础,而CPA则为临床鉴别良、恶性卵巢肿瘤提供了敏感的血流信息。Objective： To evaluate the relationship between C-erbB-2, MVD expressions in ovarian tumors and the blood flow of CPA. Methods： Fifty cases of ovarian tumors were examined preoperatively by CPA whereas C-erbB-2 and MVD were stained with immunohistochemistry after operation. Results： The positive expression rate of C-erbB-2 in malignant ovarian tumors was 83.33% which was higher than that in the benign group（30%, P〈0.05）, the MVD value of malignant ovarian tumors showed positive correlation to the degree of CPA（r=0.823, P〈0.05）, the MVD value（53.37±7.91） in the positive C-erbB- 2 groups including benign and malignant ovarian tumors was higher than that in negative C-erbB-2 group （38.93±3.19, P〈 0.05）. MVD in the malignant ovarian tumors（48.84±6.19） was higher than that in the benign group（20.90±2.71, P〈0.05）. Their MVD demonstrated a positive correlation to the degree of CPA. The RI value of malignant group（0.36±0.06） was significantly lower than that of the benign group（0.68±0.07, P〈0.05）. RI values and MVD showed negative correlation（r=-0.806, P〈0.05）. Conclusion： The expressions of C-erbB-2 and MVD for ovarian tumors support CPA pathologically and the latter provides in turn the sensitive blood flow information for diagnosis of benign and malignant ovarian tumors in clinic.

关 键 词：卵巢肿瘤超声检查 多普勒 彩色 

分 类 号：R737.31[医药卫生—肿瘤] R445.1[医药卫生—临床医学]