MMP-1、TIMP-1及PDGF在病理性瘢痕中的表达  

Expression of matrix metalloproteinase-1, tissue inhibitor of metallpreteinase-1 and platelet-derived growth factor in pathological scar

作　　者：郭丽丽[1] 刘林嶓[1] 陈言汤[1] 

机构地区：[1]郑州大学第一附属医院整形外科,河南郑州450052

出　　处：《中国美容整形外科杂志》2006年第5期340-342,共3页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：目的研究基质金属蛋白酶-1(MMP-1)、金属蛋白酶组织抑制剂-1(TIMP-1)、血小板源性生长因子(PDGF)在病理性瘢痕中的表达及意义。方法对58例病理性瘢痕手术切除标本采用免疫组化方法。结果MMP-1、TIMP-1、PDGF在病理性瘢痕中呈阳性表达(62.07%,63.71%,55.17%),在正常皮肤与普通瘢痕中几乎无阳性表达,病理性瘢痕组与两对照组差异均有显著意义(P<0.05)。病理性瘢痕中TIMP-1与PDGF呈正相关(r=0.331,P<0.05)。结论TIMP-1、PDGF促进病理性瘢痕形成;在病理性瘢痕形成过程中PDGF可促进TIMP-1的表达;病理性瘢痕的形成与MMP-1、TIMP-1、PDGF相互作用失衡有关。Objective To study the significance of expression of matrix metalloproteinase- 1 （MMP - 1）, tissue inhibitor of metalloproteinase - 1 （TIMP - 1） and platelet - derived growth factor （PDGF） in pathological scar. Methods The tissues of pathological scar were obtained from 58 patients who were underwent surgery. The polyclone antibodies of anti - MMP - 1, anti - TIMP - 1 and anti - PDGF were used to performed immunohistochemical staining （SABC method）. Results There were obvious difference about the positive rate of MMP- 1, TIMP- 1 and PDGF among pathological scar and normotrophic scar, normal skin. There was significant difference in the expression of MMP- 1, TIMP- 1, PDGF between patholocal scar group and the two control groups. There was positive correlation between the expression of TIMP- 1 and that of PDGF in patholoical scars （ r = 0. 331, P 〈 0.05 ）. Conclusion TIMP - 1 and PDGF could promote the formation of patholoical scar. PDGF could promote the expression of TIMP- 1. The mechanism of patholoical scar formation is correlate with the imbalance of regulation among MMP- 1, TIMP- 1 and PDGF.

关 键 词：增生性瘢痕 瘢痕疙瘩 基质金属蛋白酶-1 金属蛋白酶组织抑制剂-1 血小板源性生长因子 

分 类 号：R363[医药卫生—病理学]