EGR-1与p53,p16,CyclinD1在鼻咽癌中的表达及意义  

Expression and significance of EGR-1, p53, p16 and CyclinD1 in nasopharyngeal carcinoma

作　　者：钟守军[1] 姚运红[1] 李飞虹[1] 蔡琼珍[1] 

机构地区：[1]广东医学院病理学教研室

出　　处：《肿瘤研究与临床》2006年第10期664-666,共3页Cancer Research and Clinic

摘　　要：目的探讨早期生长反应基因(EGR-1)与p53,p16,CyclinD1在鼻咽癌中的表达及其意义。方法应用免疫组化SABC法检测29例鼻咽黏膜慢性炎组织、45例鼻咽癌组织、24例鼻咽癌颈部淋巴结转移灶中EGR-1与p53,p16,CyclinD1表达。结果鼻咽癌原发灶及其颈部淋巴结转移灶中EGR-1表达较鼻咽黏膜慢性炎降低,p53,CyclinD1表达则增高,差异有统计学意义(P<0.05);p16在三种病变中的表达差异无统计学意义(P>0.05)。结论EGR-1的表达降低与p53,CyclinD1的高表达可能与鼻咽癌的发生、发展有关;p16可能在鼻咽癌的发生、发展中不起作用。Objective To investigate the expressions and effects of EGR-1, p53, p16, Cyclin D1 in Nasopharyngeal Carcinoma （NPC）. Methods Expressions of EGR-1, p53, p16, and Cyclin D1 protein in paraffin-embedded specimens of 29 chronic nasopharyngitis, 45 NPC and 24 lymph-node metastasis were studied by immunohistochemical method （SABC）. Results The positive rates of EGR-1, p16, and Cyclin D1 protein expressions in chronic nasopharyngitis were 44.83 %（13/29）, 89.66 %（26/29） and 24.14 %（7/29） respectively, but no p53 protein expression. In NPC, the positive expression rates of the four proteins were 22.22 %（10/45）, 91.11%（41/45）, 53.33 %（24/45） and 66.67 %（30/45）, with significant difference eompal＇ed with chronic nasopharyngitis respectively; and in lymph nodes metastasis were 16.67 %（4/24）, 79.17 %（19/24）, 70.83 %（17/24） and 75.00 %（18/24）with significant difference compared with those of chronic nasopharyngitis and NPC respectively except for p16 protein. Spearman correlation analysis showed that there were no significant correlation between the expression of EGR-1 and p53, p16, Cyelin D1 respectively both in NPC and in lymph nodes metastasis. In NPC, the expression of p53 showed a positive correlation with the expression of p16; and in lymph nodes metastasis the expression of Cyelin D1 showed positive eorrelation with the expressions of p16 and p53. Conclusions The expression of EGR-1 protein was significantly decreased both in NPC and in lymph-node metastasis, which suggested that Egr-1 gene may be a tumor suppressor gene and have an important effect in the pathogenesis and the progression of NPC. The overexpression of p53 and Cyelin D 1 also have an important role in NPC, but p16 probably have no biological significance in NPC.

关 键 词：GR-1 P53 P16 CYELIN D1 鼻咽癌 

分 类 号：R739.63[医药卫生—肿瘤]