基质金属蛋白酶-1,3的单核苷酸多态性现象在癌症中的作用  

The role of a single nucleotide polymorphism in MMP-1 and MMP-3 in carcinoma

作　　者：韩海琼[1] 邵淑丽[2] 

机构地区：[1]山西医科大学第二临床医学院,太原030001 [2]山西省肿瘤医院妇科

出　　处：《肿瘤研究与临床》2006年第10期714-717,共4页Cancer Research and Clinic

摘　　要：基质金属蛋白酶(MMP)是肿瘤侵袭和转移过程中起关键作用的酶之一。单核苷酸多态性(SNP)是染色体DNA序列的某个位点上存在的单个碱基变化。MMP-1启动子基因在1607bp位点额外插入鸟嘌呤G,在肿瘤人群中,2G纯合子的比例高。MMP-3启动子区处有一SNP位点,MMP-35A基因型可能增加癌症淋巴转移的风险并与易感性相关。Matrix Metalloproteinases is one of the critical enzymes that produce great influence during turnout invasion and metastasis. Single nucleotide polymorphism is single basic group changed at chromosome DNA sequence in certain site. MMP-1 promotor gene additional inserts guanopterin G at site -1607bp. In the tumor crowd, 2G homozygote has higher proportion. MMP-3 promoter region has a single adenine mononucleotide polymorphism site at -1171bp. MMP-3 5A genetype may increase the risk of lymphatic metastasis and have certain correlation with susceptibility.

关 键 词：MMP-1 MMP-3 单核苷酸多态性 肿瘤侵袭 转移 

分 类 号：R730.2[医药卫生—肿瘤]