曲唑酮与氟西汀治疗抑郁症对照研究  

A controlled study of trazodone vs. fluoxetine in the treatment of depression

作　　者：万予新[1] 李梅香[1] 韩嫣[1] 马振武[1] 

机构地区：[1]新乡医学院第二附属医院,河南新乡453002

出　　处：《临床心身疾病杂志》2006年第6期420-421,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的比较曲唑酮与氟西汀治疗抑郁症的疗效及安全性。方法将65例抑郁症患者随机分为两组，研究组33例，给予曲唑酮50～200mg·d^-1治疗，对照组32例给予氟西汀20·40mg·d^-1治疗，观察6w，采用汉密顿抑郁量表、汉密尔顿焦虑量表、临床总体印象量表、副反应量表评定临床疗效及不良反应。结果治疗6w末，两组各量表评分均较治疗前有显著改善（P〈0．01），研究组治疗1w末比对照组改善显著（P〈0．05），提示研究组起效快。研究组显效率为75．8％，有效率为93．9％，对照组分别为75．0％和90．6％，两组疗效相当（P〉0．05）。两组不良反应均较轻微，无需特殊处理。结论曲唑酮治疗抑郁症疗效显著，安全性高，依从性好。Objective To compare the curative effects and safety of trazodone vs. fluoxetine in the treatment of depression. Methods 65 depressive patients were divided into research group（n=33, took trazodone 50～200mg/d） and control group （ n = 32 , did fluoxetine 20～40mg/d） for 6 weeks. The curative effects and adverse reactions were assessed with the HAMD, HAMA, CGI-SI and TESS respectively. Results After 6 week treatment, there were significant improvement in scores of all scales compared with pre-treatment（P〈0.01） ;at the end of 1st week improvement was significant in the research group than in the control group（P〈0.05）, which hinted that the research group took effects faster. Effectual and effective rates of trazodone group were 75.8% and 93.9% and of fluoxetine group 75% and 90.6%, respectively （P〉0.05）. The curative effects of the 2 groups were equivalence（P〉0.05）. The adverse reactions of both groups were milder and didn＇t need special handling. Conclusion Tazodone has an marked curative effect, higher safety and better compliance.

关 键 词：抑郁症 曲唑酮 氟西汀 汉密尔顿抑郁量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]