Runx2基因调控及其异构体的最新研究进展  

Runx2 regulation and its isoforms

作　　者：李雅琳[1] 肖洲生[1] 

机构地区：[1]中南大学临床药理研究所,湖南长沙410078

出　　处：《中国药理学通报》2006年第10期1153-1157,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30171085)

摘　　要：Runx2基因编码成骨细胞特异性转录因子,调控成骨细胞分化和骨的形成。Runx2基因主要编码两种异构体,Runx2-TypeI和Runx2-TypeII,分别在骨质形成调控中发挥不同的作用。最近发现多条信号转导通路如W nt/LRP5β/-caten in、BMP/Sm ads/DPC4、1,25二-羟维生素D/VDR/VDRE及多种调节蛋白如M sx2、D lx5、Tw ists涉及Runx2的活性或表达的调控。这些研究为药物调控成骨细胞分化和骨质形成及基因治疗骨质疏松症开拓了新的思路。Runx2 is a transcription factor essential for osteoblast differentiation and bone formation. Expression of Runx2 is initiated from two promoters, the distal P1 promoter and the proximal P2 promoter. These promoters give rise to two major protein isoforms with distinct amino termini, named as Runx2-TypeI and Runx2-TypeII. Here we review some integrated complex pathways （ Wnt/LRP5/β-catenin, BMP/Smads/DPC4, Vitamin D/VDR/VDRE pathway, etc） and several key proteins （Msx2, Dlx5, Twists, etc） necessary for regulating Runx2 activity and bone formation, which give us new hints on controlling osteoblast differentiation by drug therapy and treating osteoporosis by gene therapy.

关 键 词：Runx2基因 成骨细胞分化 表达调控 信号转导通路 异构体 

分 类 号：R-05[医药卫生] R329.21