SKP2在大肠癌组织中的表达及预后意义  

Expression and prognostic significance of S-phase kinass-associated protein 2 in colorectal carcinoma tissues

作　　者：孙立春[1] 隋广杰[1] 刘亚琴[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院内四科,黑龙江省哈尔滨市150040

出　　处：《世界华人消化杂志》2006年第25期2516-2520,共5页World Chinese Journal of Digestology

基　　金：哈尔滨市科技攻关资助项目;No.2004AA9CS196-10~~

摘　　要：目的:探讨SKP2在大肠癌中的表达和预后作用．方法:采用SP免疫组化法检测68例大肠癌手术切除组织标本中SKP2和P27的表达,用Kaplan-Meier和Cox回归分析法进行生存分析．结果:在68例大肠癌组织中,SKP2和P27的阳性表达率分别为41．2％(n=28)和52．9％(n= 36)．SKP2的表达与组织分级显著相关(X2= 14．073,P=0．001)．SKP2表达与年龄、性别和AJCC分期无关(P>0．05)．SKP2和P27负相关(r=-0．528,P=0．0001)．SKP2高表达组的总生存期较SKP2低表达组短(31．5±4．0 mo vs 54．5±2．1 mo,P<0．01)．多因素Cox回归分析表明,SKP2表达是大肠癌的独立预后因素(RR= 6．227．P=0．033)．结论:SKP2表达可以作为大肠癌患者预后的指标．AIM： To detect the expression of S-phase kinase associated protein 2 （SKP2） and assess its prognostic value in human colorectal carcinoma. METHODS： SP immunohistochemical method was used to detect the expression of SKP2 P27 proteins in the tissues of colorectal carcinoma （n = 68）. Survival analyses were performed using the Kaplan-Meier method and Cox regression model, RESULTS： Of 68 cases with colorectal carcinoma, the positive rates of SKP2 and P27 expression were 41.2% （n = 28） and 52,9% （n = 36）. The expression of SKP2 was significantly correlated with the differentiation of carcinoma （χ^2 = 14,073, P = 0.001）, but it had no significant correlation with tumor AJCC staging, the gender and ages of patients （P 〉 0,05）. There was a negative correlation between SKP2 and P27 expression （r = -0.528, P = 0.0001）. With regard to prognosis, the overall survival rate for patients with the high-SKP2 expression was significantly lower as compared with that for the ones with low- SKP2 expression （31.5 ± 4.0 mo vs 54.5 ± 2.1 too, P 〈 0.01）. Furthermore, the expression of SKP2 was an independent predictor of prognosis by multivariate Cox regression model analysis （RR = 6.227, P = 0.033）. CONCLUSION： SKP2 expression can serve as a useful prognostic marker in colorectal carcinoma patients.

关 键 词：S期激酶相关蛋白2 大肠癌 预后 

分 类 号：R735.34[医药卫生—肿瘤]