急性脑梗死及并发肺部感染患者血清C反应蛋白水平的变化  

Change of serum C-reactive protein level in patients with acute cerebral infarction and acute cerebral infarction with pulmonary infection

作　　者：肖峰[1] 王焱烽[1] 刘艳菲[1] 姚茂元[1] 尚进[1] 蒋苏莉[1] 

机构地区：[1]南京医科大学附属淮安第一医院神经内科,223300

出　　处：《神经疾病与精神卫生》2006年第5期338-339,共2页Journal of Neuroscience and Mental Health

摘　　要：目的 探讨急性脑梗死及其并发肺部感染患者血清C反应蛋白（CRP）水平的变化及其意义。方法 采用免疫散射比浊法测定20例健康体检者（对照组）和55例脑梗死患者（按梗死面积分为大、中、小3组）血清CRP含量，中等面积梗死患者据是否合并肺部感染分组，于入院7d后复测CRP。结果 CRP含量为大面积梗死组〉中面积梗死组〉小面积梗死组〉对照组，组间差异均具显著性（P〈0．05～0．01）。中面积梗死组，1周后并发感染者较入院1d时CRP含量增高，未并发感染者降低（均为P〈O．01）；中面积梗死者，入院时CRP含量虽无显著性差异（P〉0．05），1周后感染者较未感染者CRP含量显著升高（P〈0．01）。结论 血清CRP含量反映脑梗死严重程度，动态观察对了解有无合并感染的病情变化有帮助。Objective To investigate the change of serum C-reactive protein （CRP） level in patients with acute cerebral infarction （ACI） and ACI with pulmonary infection. Methods The serum CRP level was measured by immune transmission turbidity method in 20 normal control healthy people and in 55 patients with ACI that were divided into three groups according to the infarct volume（ large , moderate and small）. And the CRP level was measured again at day 7 in patients with moderate infarct volume that were divided into two groups whether with pulmonary infection or not. Results The CRP level in patient group was positively correlated with the infarct volume, the CRP level of patients with pulmonary infection were significantly higher than those without infection although they were no significant different at day 1. Conclusions Serum CRP level is an important marker to evaluate the severity of cerebral infarction and complication with pulmonary infection.

关 键 词：C反应蛋白 脑梗死 肺部感染 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R563.1[医药卫生—临床医学]