两种应用氟西汀维持治疗惊恐障碍的临床疗效比较  

Once weekly dosing of fluoxetine in the maintenance treatment of panic disorder

作　　者：黄雄 马静山[1] 麦桂英[1] 钟天平[1] 

机构地区：[1]广州市精神病医院,510370

出　　处：《神经疾病与精神卫生》2006年第5期358-360,共3页Journal of Neuroscience and Mental Health

摘　　要：目的比较每周1次与每天1次氟西汀维持治疗惊恐障碍临床疗效。方法将45例已接受每天1次氟西汀治疗,且临床疗效已达治愈的惊恐障碍患者,随机分为研究组(22例)和对照组(23例),研究组在观察期前2周开始改变原用药方法,第1周改为隔日1次用药,第2周改为每周2次用药,观察组改为每周1次用药。对照组原用药方法不变,每天1次使用氟西汀治疗,疗程3个月。采用汉密尔顿焦虑量表(HAMA)和副反应症状量表(TESS)评定疗效和药物不良反应。结果研究组与对照组在治疗前后组内和组间HAMA评分比较都无显著差异;研究组在治疗后4、8、12周的累计保持率分别为:100%、95.2%、90.5%;对照组分别95.6%、95.6%、95.6%;两组比较都无显著差异(P>0.05)。结论经过急性期治疗临床症状已达治愈的惊恐障碍患者,采用氟西汀每周1次的治疗方案,也可以维持原有疗效。Objective To compare the efficacy of daily dosing and once weekly dosing of fluoxetine in the maintenance treatment of panic disorder （PD）. Methods After being treated initially with daily doses of fluoxetine and having been improved,45 patients with PD were randomly assigned to study group （n=22） and control group （n=23） for 12 weeks. The study group switched to qod dosing in the first week and then twice weekly dosing in the second week, and switched to once weekly dosing from the third week. The control group continued daily dosing regimen. Assessment scales included Hamilton rating scale for anxiety （HAMA）and treatment emergent symptom scale（TESS）. Results There were no significant difference in HAMA in two groups before and after the maintenance treatment. The cumulative rate of the study group at 4,8,12 week was similar in control group. Conclusions It is suggested that once weekly fluoxetine dosing is effective in the maintenance treatment of PD.

关 键 词：氟西汀 惊恐障碍 维持治疗 

分 类 号：R749.7[医药卫生—神经病学与精神病学]