纳洛酮对IL-1β致热大鼠体温及下丘脑中cAMP和HSP70含量的影响  

Effects of naloxone on IL-1β-induced fever and the content of cAMP and HSP70 in hypothalamus in rats

作　　者：秦鑫[1] 曹宇[1] 王慧玲[1] 赵红艳[1] 赵书芬[1] 

机构地区：[1]中国医科大学基础医学院生理学教研室,辽宁沈阳110001

出　　处：《中国药理学通报》2006年第10期1180-1183,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30270198)

摘　　要：目的研究阿片受体在IL-1β致热大鼠发热过程中的作用及机制。方法经大鼠侧脑室微量注射纳洛酮和(或)IL-1β,观察大鼠体温变化情况,并测定下丘脑中cAMP含量和HSP70表达。结果纳洛酮能够减弱IL-1β致热效应,同时下丘脑中cAMP含量和HSP70表达水平也相应减少(P<0.01)。结论阿片受体拮抗剂纳洛酮能够抑制大鼠IL-1β性发热,其机制可能与降低下丘脑中cAMP的合成有关;同时可见HSP70表达水平降低。Aim To study the role and mechanism of opioid receptor on IL-1β-induced fever. Methods Rats were dealed with intracerebreventricular administration of naloxone and/or IL-1β. Changes in body temperature were measured. The content of cAMP and HSP70 expression in hypothalamus were detected. Resuits Naloxone can limit IL-1β-induced fever and decrease the content of cAMP and HSP70 expression inhypothalamus（P 〈 0.01 ）. Conclusion The present study showed that the opioid receptor antagonist naloxone could inhibit IL-1β-induced fever in rats, and this mechanism might be related with the decrease of cAMP synthesis in hypothalamus; meanwhile the expression of HSP70 was reduced.

关 键 词：发热 纳洛酮 白细胞介素1-Β 环磷酸腺苷 热休克蛋白70 

分 类 号：R-332[医药卫生] R342.4