超声引导下注射氨甲喋呤治疗子宫肌瘤的临床疗效与血流变化观察  

Clinical observation of ultrasound-guided injection of MTX into uterine leiomyoma

作　　者：苑洪菲[1] 王晓蓉[1] 车丽萍[1] 伏胜香[1] 张伟[1] 崔洪艳[1] 

机构地区：[1]武警黑龙江省总队医院妇产科,黑龙江哈尔滨150076

出　　处：《哈尔滨医科大学学报》2006年第5期412-415,共4页Journal of Harbin Medical University

摘　　要：目的探讨超声引导下经阴道瘤体内注射氨甲喋呤（MTX）治疗子宫肌瘤的临床疗效及血流变化。方法对31例子宫肌瘤患者在超声引导下经阴道瘤体内注射MTX治疗，剂量50—60mg，每月1次，连续注射3个月，超声下观察肌瘤体积和注射前后血流信号变化。结果治疗后所有患者临床症状改善或消失，月经恢复正常，无严重并发症发生。注药1个月后肌瘤体积与治疗前相比无明显变化（P〉0．05）；第2、3次注药1个月后肌瘤体积与治疗前相比明显缩小（P〈0．01），注药6个月后肌瘤体积与注药3个月后相比较差异无显著性意义（P〉0．05）。注药后肌瘤内血流信号明显减少。结论行超声引导下经阴道瘤体内注射MTX治疗子宫肌瘤，近期疗效明显，操作简单，副作用小。Objective To investigate the efficiency and safety of the treatment of uterine leiomyoma by the ultrasound-guided injection of MTX into leiomyoma transvaginally. Methods Thirty-three cases of uterine myomas were treated by the ultrasound-guided injection of MTX into leiomyoma transvaginally. 50 - 60mg of MTX was injected into leiomyoma once a month for 3 consecutive months. The changes of myoma size and blood supply before and after the injection were observed with ultrasound. Results All of the clinical symptoms showed better or disappeared, the menstrual cycle was normal, no serious complications occurred. The mean tumor size of 31 patients was not significantly different between one month after the first injection and before the injection （ P 〉 0. 05）. One month after the second and third injections, the tumor sizes were significantly decreased, compared with those before the treatment （ P 〈 0.01 ）. At 6 month the tumor size was not significantly different from that at 3 months （ P 〉 0.05 ）. The blood flow signals in hysteromyomaswas significantly decreased. Conclusion The Ultrasound-guided injection of MTX into leiomyoma transvaginally has satisfactory definite short-term effect. It is easily operated and has little side effect.

关 键 词：子宫肌瘤 超声引导 氨甲喋呤 

分 类 号：R737.33[医药卫生—肿瘤]