肿瘤转移抑制基因KAI1在原发性胆囊癌中的表达及其临床意义  

Metastatic suppressor Kangai 1 in primary gallbladder carcinoma:expression and clinical significance

作　　者：姜文霞[1] 宋伯根[1] 汤如勇[2] 方建萍[2] 

机构地区：[1]同济大学医学院病理学教研室,上海200092 [2]同济大学附属同济医院病理科,上海200065

出　　处：《第二军医大学学报》2006年第10期1101-1104,共4页Academic Journal of Second Military Medical University

摘　　要：目的:研究肿瘤转移抑制基因KAI1在原发性胆囊癌中的表达及其临床意义。方法:将35例原发性胆囊癌患者按照国际抗癌联合会(UICC)胆囊癌的TNM分期进行临床分期,病理标本分别行常规H-E染色及免疫组化染色以了解其病理组织学分级和肿瘤转移抑制基因KAI1的表达。所有病例随访3年。结果:35例原发性胆囊癌中:原位癌1例(0期),早期癌13例(Ⅰ期2例;Ⅱ期11例),中晚期癌21例(Ⅲ期13期;Ⅳ期8例);病理组织学分级:高分化癌14例,中分化癌10例,低分化癌11例。KAI1基因蛋白阳性表达者21例,其中早期阳性表达率为92.31%(12/13),高于晚期的42.86%(9/21)(P确切=0.004 76),且KAI1基因蛋白阳性表达率与胆囊癌的临床分期呈负相关(P趋势=0.004)。高分化胆囊癌中KAI1基因蛋白阳性表达率为92.86%(13/14),中分化癌为60.00%(6/10),低分化癌为18.18%(2/11),三组有显著性统计学差异(P确切=0.004 75),且KAI1基因蛋白阳性表达率与胆囊癌的病理组织学分级呈正相关(P趋势=0.001)。三年存活的19例中KAI1基因蛋白阳性表达占89.47%(17/19),死亡16例中KAI1基因蛋白阳性表达占25.00%(4/16),有显著性统计学差异(P=0.001)。结论:KAI1基因蛋白与胆囊癌的临床分期呈负相关;与病理组织学分级呈正相关;KAI1基因蛋白的高表达预示着胆囊癌患者有较好的预后。Objective：To investigate the expression of metastatic suppressor Kangai1 （KAI1） expression in the primary gallbladder carcinoma and its clinical significance. Methods： The clinical stages of 35 primary gallbladder carcinoma patients were determined according to the TNM criteria of International Union Against Cancer （UICC）. Histopathologic changes and the expressions of KAI1 were detected by H-E and immunohistochemical methods, respectively. All the patients were followed up for 3 years. Results： It was found that 1 patient had carcinoma in situ （0 stage） , 13 had early carcinoma （ Ⅰ-Ⅱ stage）, and 21 had intermediate or advanced carcinoma （ Ⅲ-Ⅳ stage）. Histopathologic grading showed that 14 patients had well-differentiated carcinomas, 10 had moderately differentiated ones, and 11 had poorly differentiated ones. Immunohistochemical results revealed that 60.00% （21/35） of the patients were positive of KAI1, with the positive rate being 92.31% （12/13） in early carcinoma （ Ⅰ-Ⅱ stage） and 42.86% （9/21） in intermediate and advanced carcinoma （ Ⅲ-Ⅳ stage）, and the former was significantly higher than the latter （Pexact=0.00 476）. The positive rate of KAI1 protein was negatively correlated with the clinical staging of patients （Ptrend =0. 004） and positively correlated with histopathologic grading （Ptrend=0. 001）. The positive rate of KAI1 protein in well differentiated carcinoma was 92.86% （13/14） , in moderately differentiated carcinoma was 60.00% （6/10）, and in poorly differentiated carcinoma was 18.18% （2/11） （Pxact=0.000 475 between the 3 groups）. The positive rate of KAI1 protein was 89.47% （17/19） in 19 survival patients and 25.00% （4/16） in 16 death cases. Obvious significance of the expression of KAI1 protein was found between the 2 groups （P=0.001）. Conclusion： The positive rate of KAI1 is negatively correlated with the clinical staging but positively correlated with the histopathologic grading in patients wit

关 键 词：胆囊肿瘤 KAI1 临床分期 病理组织学分级 

分 类 号：R735.8[医药卫生—肿瘤]