慢性非细菌性前列腺炎患者血清细胞因子水平与病原体感染的相关性研究  

Study on the relationship between serum cytokine level in patients with chronic abacterial prostatitis and pathogen infection

作　　者：李树平[1] 孟双艳[2] 唐孝亮[2] 李锐[3] 

机构地区：[1]湖南怀化医学高等专科学校检验系,怀化418000 [2]怀化市第一人民医院检验科 [3]怀化医学高等专科学校附属医院检验科

出　　处：《中国男科学杂志》2006年第10期4-7,共4页Chinese Journal of Andrology

基　　金：湖南省教育厅科研基金项目(03C041)

摘　　要：目的探讨血清细胞因子与引起慢性非细菌性前列腺炎(CAP)病原体的关系。方法用ELISA法对112例CAP患者(其中CAPⅠ组80例,CAPⅡ组32例)血清进行IL-2、IL-4、IL-8、TNF-α检测, PCR法检查衣原体、支原体、病毒(HPV、HSV),同时,以20例健康男性作正常对照,并对所取得的数据进行统计学分析。结果(1)CAPⅠ组血清中的IL-2、IL-4、IL-8、TNF-α均有不同程度的升高,与CAPⅡ组和正常对照组相比差异显著(P<0．01或P<0．05),CAPⅡ组血清中IL-2、IL-4、TNF-α与正常对照组比较无显著性差异(P>0．05);(2)衣原体、支原体感染患者血清中的IL-2、IL-4、IL-8、TNF-α与对照组相比差异显著(P<0．01或P<0．05),痫毒感染患者血清中的IL-2、TNF-α与对照组比较有显著性差异(P<0．01或P<0．05),未检出病原体患者血清中的IL-2、IL-4、TNF-α与对照组比较差异无显著性(P>0．05)。结论血清IL-2、IL-4、IL-8、TNF-α水平与CAP病原体间有一定的相关性,它们在CAP发生发展过程中可能起着重要作用,对CAP辅助性诊断有较大应用价值。Objective To investigate the relationship between level of cytokines in serum and the pathogen causing chronic abacterial prostatitis （CAP）. Methods The levels of interleukin-2（IL-2）, interleukin-4 （IL-4）, interleukin-8 （IL-8）, tumor necrosis factor- α（TNF- α） were detected in 112 patients with CAP by ELISA, Chlamymia, Mycomplasma, virus （HPV, HSV）were detected by PCR. 20 healthy male were treated as control. Results （1）The serum levels of IL-2, IL-4, IL- 8, TNF-α in patients with CAP Ⅰ were significantly higher than those of CAP Ⅱ, control and difference was obvious between them （P〈0.01 or P〈0.05）, there were no significant difference between CAP Ⅱ and control （P〉0.05） in the serum levels of IL-2, IL-4, TNF-α. （2）The serum levels of IL-2, IL-4, IL-8, TNF-α in patients with infection of Chlamymia, Mycomplasma were higher obviously when compares with control （P〈0.01 or P〈0.05）, the difference were obvious in serum levels of IL-2, TNF-α in patients with infection of virus compares with control （P〈0.01 or P〈0.05）, the serum levels of IL-2, IL-4, TNF-α of patients with infection of no pathogen there were no significant difference compares with control （P〉0.05）. Conclusion There is correlation between the serum levels of IL-2, IL-4, IL-8, TNF-α and the pathogen of CAP, they may play an important roles in process of the occurrence and development of CAP, and are helpful for diagnosis of CAP.

关 键 词：前列腺炎/免疫学 微生物学 细胞因子 

分 类 号：R697.33[医药卫生—泌尿科学] R392.11[医药卫生—外科学]