进一步加强对中枢神经系统白血病早期预防性治疗的认识  

Toward intensify recognization of early prophylactic treatment in central nervous system leukemia

作　　者：郑昌成[1] 吴竞生 王祖贻[1] 

机构地区：[1]安徽医科大学附属省立医院血液内科,合肥230001

出　　处：《白血病．淋巴瘤》2006年第5期321-322,共2页Journal of Leukemia & Lymphoma

摘　　要：国内多在急性淋巴细胞白血病(ALL)完全缓解后才开始腰穿和鞘内注射(鞘注)进行中枢神经系统白血病(CNS-L)的预防;而国外多在初次诱导的第1天即行腰穿、鞘注,有助于初诊ALLCNS状态的评价,并且使得潜在的CNS-L得到早期有效的治疗。正确了解初诊ALL脑脊液中存在少许原始细胞和腰穿鞘注损伤对预后的影响,有助于CNS-L治疗模式向早期预防性转变。Prophylactic treatment of central nervous system leukemia （CNS-L）, such as lumbar puncture and intrathecal chemotherapy, can only be done after complete remission of acute lymphoblastic leukemia （ALL） in China. But in abroad, at the same time of induction chemotherapy of ALL in the first day, lumbar puncture and intrathecal chemotherapy will be managed to evaluate the status of CNS, in order to make early and effective treatment of the potential CNS-L. The proper understanding of significance of low leukocyte counts with blasts in cerebrospinal fluid or traumatic lumbar puncture in newly diagnosed ALL, will help scholars switch to the patterns of early prophylactic treatment of CNS-L in China.

关 键 词：中枢神经系统白血病 预防性治疗 

分 类 号：R739.4[医药卫生—肿瘤]