急性髓系白血病合并慢性淋巴细胞白血病一例报道及文献复习  

Acute myelogenous leukemia concurrent with chronic lymphocytic leukemia one case report and review literature

作　　者：刘凯奇[1] 秘营昌[1] 李大鹏[1] 白洁[1] 井丽萍[1] 卞寿庚[1] 王建祥[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所血液病医院血液内科,天津300020

出　　处：《白血病．淋巴瘤》2006年第5期344-346,共3页Journal of Leukemia & Lymphoma

摘　　要：目的探讨急性髓系白血病(AML)合并慢性淋巴细胞白血病(CLL)的临床特点、病因、诊断、治疗及预后。方法临床诊断1例AML合并CLL,并就相关文献进行复习。结果患者经MA方案(米托蒽醌10mg/d第1￣3天,阿糖胞苷150mg/d第1,3,5,7天,200mg第2,4,6天)化疗后取得完全缓解,但CD19阳性的淋巴细胞(表达CD20,CD23,SIgM,部分表达CD5,CD22,CD25)仍然存在,于9个月后AML复发未能再次缓解而死亡。结论AML合并CLL为一种具有特殊生物学特征的罕见疾病,免疫分型和细胞遗传学技术在疾病的诊断和认识中发挥重要作用,治疗应以AML为主。Objective To investigate the clinical characteristics, pathogenesis, diagnosis, therapeutics and prognosis of acute myelogenous leukemia （AML） concurrent with chronic lymphocytic leukemia （CLL）. Methods One case of AML concurrent with CLL was diagnosed and literatures were reviewed. Results The patient achieved complete remission with MA regimen. But the lymphocytes that expressing CD19, CD20, CD23, SIgM positive （ part of the cell CD5, CD22, CD25 positive） were still existing. The patient died of AML relapse 9 months later. Conclusion The concomitant AML and CLL is a rare disease with particular biological characteristic. Flow cytometry and cytogenesis are helpful to diagnose and recognize the disease. Therapeutics always uses the regimen of the AML.

关 键 词：急性髓系白血病 慢性淋巴细胞白血病 

分 类 号：R733.7[医药卫生—肿瘤]