急性混合细胞性白血病八例的临床及生物学特征  

Clinical and biological features of 8 cases of acute mixed leukemia

作　　者：王珏[1] 顾中华[1] 李小雯[1] 谢新[1] 毛玉文[2] 李天宇[2] 

机构地区：[1]无锡市第一人民医院检验科,214002 [2]无锡市第一人民医院血液科,214002

出　　处：《白血病．淋巴瘤》2006年第5期362-364,共3页Journal of Leukemia & Lymphoma

摘　　要：目的研究急性混合细胞性白血病(MAL)的临床特征、实验室指标、治疗及预后。方法对8例MAL骨髓标本均进行细胞形态学、免疫学、遗传学分析,运用急性淋巴细胞白血病化疗方案或兼顾髓、淋二系方案化疗。结果FAB分型显示急性淋巴细胞白血病(ALL-L2)3例,ALL-L14例,急性髓系白血病(AML-M1)1例,免疫分型显示MAL患者均有髓、淋二系表达,其中3例为T、B、髓3系共表达。染色体核型分析可见异常核型,但无特征性改变。该类患者大多数对治疗反应差,预后不良。结论MAL具有独特的临床和生物学特征,通常预后较差。Objective To study the clinical biological features and prognosis of acute mixed leukemia （MAL）. Methods All 8 patients were evaluated to prove the diagnosis and classification by morphologic, cytochemical and immunologic cytogenetic （MIC） examinations, and these patients were treated with projects suitable for acute lymphoblastic leukemia （ALL） or acute myeloid leukemia, or both. Results FAB classification showed 4 cases were ALL-L1, 3 cases were ALL-L2, 1 case was AML-M1. Immunologically, coexpression of myeloid and lymphoid lineage associated antigens was detected and CD34, CD38 were hyperexpressed in all cases. 3 of them had T, B and myeloid lineage coexpression. Cytogenetically, there was no special disorder in these patients. Though abnormal karyotypes were observed in 4 cases. Both the treatment response and prognosis of MAL patients were poor. Conclusion MAL patients have unique clinical, biological features and poor prognosis.

关 键 词：急性混合细胞性白血病 生物学特征 

分 类 号：R733.71[医药卫生—肿瘤]