高效液相色谱法测定复方氨酚烷胺胶囊中三组分含量  

Determination of Paracetamol,Caffeine and Chlorphnamine Maleate in Compound Paracetamol and amantadine Hydrochloride Capsules by HPLC

作　　者：王早斌 张红 

机构地区：[1]江苏省宿迁药品检验所,江苏宿迁223800

出　　处：《中国药业》2006年第18期20-21,共2页China Pharmaceuticals

摘　　要：目的建立用高效液相色谱法测定复方氨酚烷胺胶囊中对乙酰氨基酚、咖啡因、马来酸氯苯那敏含量的方法。方法采用ODSC18柱(150mm×4.6mm,5μm),以甲醇-0.05mol/L磷酸二氢钾-三乙胺(20∶80∶0.02)为流动相。结果对乙酰氨基酚、咖啡因、马来酸氯苯那敏浓度线性范围分别为101.272～911.448,6.356～57.204,0.804～7.236μg/mL,平均回收率分别为99.21%,100.14%,101.37%,RSD分别为0.25%,0.27%,0.60%(n=5)。结论该方法准确、简便、快速,适于复方氨酚烷胺胶囊的含量测定。Objective To develop a HPLC method for determination of paracetamol,caffeine and chlorphnamine maleate in compound paracetamol and amantadine hydrochloride capsules. Methods ODS C18 column was used and the mobile phase was methanol-0. 05 mol/L potassium dihydrogen phosphate-triacetamide （20：80：0. 02）. Results The calibration curves for paracetamol,caffeine and chlorphnamine maleate were linear over the range of 101. 272 - 911. 448,6. 356 - 57. 204,0. 804 - 7. 236 μg/mL, respectively. The average recovery rates were 99.21% , 100. 14% , 101.37% with RSD were 0. 25% ,0. 27% and 0. 60% （ n = 5）,respectively. Conclusion The method is accurate, rapid and simple,bing applicable for the assay of compound paracetamol and amantadine hydroehloride capsules.

关 键 词：复方氨酚烷胺胶囊 对乙酰氨基酚 咖啡因 马来酸氯苯那敏 高效液相色谱法 

分 类 号：R927.2[医药卫生—药学] R971.1