乌司他丁在急性胰腺炎治疗中剂量-效果-成本关系的分析  

The Relationship Analysis of Dose - effectiveness - Cost of Ulinastatin in The Treatment of Acute Pancreatitis.

作　　者：柯传烽[1] 雷建[1] 黄炯强[1] 何健标[1] 叶熹罡[1] 

机构地区：[1]广州医学院附属第一医院普通外科,广东广州510120

出　　处：《健康大视野（医学版）》2006年第11期1-3,共3页Health Horizon:Medical Science Fascicule

摘　　要：目的 对乌司他丁在急性胰腺炎治疗中不同剂量组的效果及成本进行评价，为临床提供用药依据。方法 以我院近2年75例急性胰腺炎为对象，进行随机分组用药，观察疗效，同时运用药物经济学方法进行剂量-效果-成本分析评价。结果 在急性轻症胰腺炎组中，有效剂量与疗效无明显关系，剂量与治疗费相关；而较大剂量在急性重症胰腺炎中的应用是强要的，但治疗费除与剂量相关外，还与并发症的出现有关。结论 为获得满意的效价比的前提是准确判断病情而合理使用乌司他丁。Objective To evaluate the effectiveness and cost in the different - dose ulinastatin groups in the treatment of acute pancreatitis,and provide the evidence for the clinical medication. Methods To randomly divided 75 patients with AP in our hospital during recent 2 years into different - dose groups,and then observe the effectiveness and evaluate the relationship of dose- effectiveness-cost by the pharmacoeconomics method. Results There is no significant relationship between curative dose and effectiveness in minis acute pancreatitis（MAP）, but the cost of treament is correlated to dose. It is necessary to use larger dose in the treament of severe acute pancreatitis（SAP） ,but the cost of treament is correlated to the dose and appearance of complications. Conclusions In order to obtain the satisfactory potency ratio, we should make the exact judgement about cases,and then reasonably use ulinastatin.

关 键 词：乌司他丁 胰腺炎 急性 剂量-效果-成本分析 

分 类 号：R576[医药卫生—消化系统]