血清、涎液和胃液中表皮生长因子水平变化在胃部疾病患者的临床意义  

The alterations of serum, saliva and gastric juice epidermal growth factor in patients with gastric diseases

作　　者：戎利军[1] 陈永生[1] 

机构地区：[1]临沂市人民医院,山东临沂276003

出　　处：《健康大视野（医学版）》2006年第11期5-6,共2页Health Horizon:Medical Science Fascicule

摘　　要：目的 探讨人体液中表皮生长因子（hEGF）水平的变化与胃部疾病之间的关系。方法 应用放射免疫分析法（RIA）检测慢性胃炎65例、胃溃疡36例、十二指肠溃疡48例、胃癌33例和20例正常人血清、涎液和胃液中hEGF水平。结果 血清、涎液和胃液中hEGF水平（μg／L）慢性胃炎组-9正常对照组比较（分别为0．86±0．33、2．57±1．54、1、59±1、35与90．90±0．33、2．74±1、31、1．81±0．90），差异均无显著性（P〉0．05）；DU组（分别为1．05±0．45、2．10±1．07、1．18±0．63）与正常对照组比较，血清中差异无显著性（P〉0．05），涎液和胃液中hEGF水平均显著低于正常对照组（P〈0．05）；GU组（分别为1．26±0．64、2．10±0．98、1．25±0．99），hEGF水平均显著低于正常对照组（P〈0．05）；对PU患者各病期之间比较，血清、涎液和胃液中hEGF水平均呈A期〈H期〈S期，此种变化在涎液中最为显著。胃癌组（分别为1．35±0．67、2．97±1．48、1．54±0．90），血清中hEGF水平显著高于正常对照组（P〈0．05），涎液、胃液中hEGF水平与正常对照组比较差异无显著性（P〉0．05）。结论 测定涎液hEGF水平对PU患者的诊断和应用hEGF治疗Pu提供了客观依据，检测血清hEGF水平有助于胃癌的临床诊断及评估预后。Objective To study the alterations of epidermal growth factor in patients with gastric diseases. Methods The hEGF levels of serum, saliva and gastric juice were determined using radioimmunoassay in 65 cases of chronic gastritis, 36 cases of GU,48 cases of DU, 33 eases of gastric cancer and 20 healthy subjects. Results The hEGF levels （μg/L） of serum, saliva and gastric juice in patients with chronic gastritis （0.86 ± 0.33,2.57 ± 1.54 , 1.59 ± 1.35） and normal control group （0.90 ± 0.33,2.74 ± 1.31,1.81 ± 0.90） were not statistically different （ P 〉 0.05）. The hEGF levels of serum （ 1.05 ± 0.45） in patients with DU and normal control group were not statistically different （ P 〉 0.05）, the hEGF levels of saliva （2.10 ± 1.07） and gastric juice （ 1.18 ± 0.63） in patients with DU were lower than that in normal control group （ P 〈 0.05）. The hEGF levels of serum, saliva and gastric juice in patients with GU （ 1.26 ± 0.64,2.10 ± 0.98, 1.25 ± 0.99） were lower than that in normal control group （ P 〈 0.05）. The hEGF levels of serum,saliva and gastric juice with A stage of PU lower than that in H stage,and H stage lower than that in S stage,especially in saliva. The hEGF levels of serum in patients with gastric cancer （ 1.35 ± 0.67） were lower than that in normal control group （ P 〈 0.05）. Conclusions To determined the hEGF levels in saliva can be used in diagnosis and treatment of peptic ulcer, the serum hEGF can he a reliable indicator in clinical diagnosis and prognosis to evaluate of gastric cancer.

关 键 词：消化性溃疡 胃癌 表皮生长因子 血清 涎液 胃液 

分 类 号：R573[医药卫生—消化系统]